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  1. Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE)...

    Authors: Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M. Nishiguchi, Hiroshi Kunikata and Toru Nakazawa
    Citation: BMC Ophthalmology 2020 20:126
  2. Outcome measurements currently used in chronic uveitis care fail to cover the full patient perspective. The aim of this study is to develop a conceptual model of the factors that adult patients with chronic uv...

    Authors: Aline C. Stolk-Vos, Hamasa Kasigar, Karlijn J. Nijmeijer, Tom O. Missotten, Jan J. Busschbach, Joris J. van de Klundert and Leonieke W. Kranenburg
    Citation: BMC Ophthalmology 2020 20:125
  3. Eye infection is a public health problem in developing countries including Ethiopia. Bacteria are major causative agents of eye infections that can lead to loss of vision. The objective of this study was to de...

    Authors: Ahmed Adem Mohammed, Musa Mohammed Ali and Mengistu Hailemariam Zenebe
    Citation: BMC Ophthalmology 2020 20:124
  4. Several previous studies reported a greater prevalence of dry eye syndrome (DES) among patients with psychiatric diseases. The aim of this study is to investigate the prevalence and risk factors of DES in pati...

    Authors: Chiao-Ying Liang, Wai-Man Cheang, Chun-Yuan Wang, Keng-Hung Lin, Li-Chen Wei, Yu-Yen Chen and Ying-Cheng Shen
    Citation: BMC Ophthalmology 2020 20:123
  5. Intravitreal injections are a mandatory treatment for macular edema due to nAMD, DME and RVO. These chronic diseases usually need chronic treatment using intravitreal injections with anti-VEGF agents. Thus, ma...

    Authors: Ingo Volkmann, Katharina Knoll, Mareile Wiezorrek, Oliver Greb and Carsten Framme
    Citation: BMC Ophthalmology 2020 20:122
  6. Pupillary evaluation is a crucial element of physical exams. Noting size, reactivity, and consensual response is critical in assessing for optic nerve dysfunction. We aim to establish normative data for scotop...

    Authors: Sanket S. Shah, Hantamalala Ralay Ranaivo, Rebecca B. Mets-Halgrimson, Karen Rychlik and Sudhi P. Kurup
    Citation: BMC Ophthalmology 2020 20:121
  7. The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration....

    Authors: Kimberly M. Brothers, Nicholas A. Stella and Robert M. Q. Shanks
    Citation: BMC Ophthalmology 2020 20:120
  8. Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (M...

    Authors: Yinchen Shen, Mo Li, Kun Liu, Xiaoyin Xu, Shaopin Zhu, Ning Wang, Wenke Guo, Qianqian Zhao, Ping Lu, Fudong Yu and Xun Xu
    Citation: BMC Ophthalmology 2020 20:119
  9. Peters plus syndrome (PPS) is a combination of congenital Peters anomaly and systemic abnormalities. It is inherited most commonly in an autosomal recessive pattern with homozygous B3GLCT mutations. Ocular findin...

    Authors: Ye Elaine Wang, Dhariana Acon Ramirez, Ta Chen Chang and Audina Berrocal
    Citation: BMC Ophthalmology 2020 20:118
  10. A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surge...

    Authors: Henry Bair, Chun-Ju Lin, Chun-Ting Lai, Ning-Yi Hsia and Yi-Yu Tsai
    Citation: BMC Ophthalmology 2020 20:117
  11. To evaluate the feasibility of a surgical technique using a sub-perfluoro-n-octane (PFO) injection of ocular viscoelastic device (OVD) to stabilize inverted internal limiting membrane (ILM) flap for the treatm...

    Authors: Chi-Chun Lai, An-Lun Wu, Hung-Da Chou, Wee Min Teh, Kuan-Jen Chen, Yen-Po Chen, Laura Liu, Yih-Shiou Hwang and Wei-Chi Wu
    Citation: BMC Ophthalmology 2020 20:116
  12. This study aimed to evaluate the visual and morphological outcomes of intravitreal anti-VEGF therapy and the recurrence for idiopathic choroidal neovascularization (ICNV).

    Authors: Qianru Wu, Xiaoyong Chen, Kang Feng, Yuling Liu, Chun Zhang and Lin Zhao
    Citation: BMC Ophthalmology 2020 20:115
  13. Classification of optical coherence tomography (OCT) images can be achieved with high accuracy using classical convolution neural networks (CNN), a commonly used deep learning network for computer-aided diagno...

    Authors: Takumasa Tsuji, Yuta Hirose, Kohei Fujimori, Takuya Hirose, Asuka Oyama, Yusuke Saikawa, Tatsuya Mimura, Kenshiro Shiraishi, Takenori Kobayashi, Atsushi Mizota and Jun’ichi Kotoku
    Citation: BMC Ophthalmology 2020 20:114
  14. Bilateral diffuse uveal melanocytic proliferation (BDUMP) is an extremely rare paraneoplastic syndrome, with most cases reported as secondary to female urogenital and male lung malignancies. We reported this c...

    Authors: Mingyue Luo, Zhe Chen, Yaping Luo, Lin Zhao, Rongping Dai and Yong Zhong
    Citation: BMC Ophthalmology 2020 20:113
  15. In this case presentation, we present a young vegan patient who developed a CRVO secondary to severe iron-deficiency anaemia (IDA) attributable to menstrual losses and limited iron intake. CRVO is a rare compl...

    Authors: Verlyn Yang, Liam Daniel Turner and Fraser Imrie
    Citation: BMC Ophthalmology 2020 20:112
  16. The aim of this study was to evaluate the efficacy and safety of M22 Optimal Pulsed Technology (OPT) applied in patients with age-related cataract and Meibomian gland dysfunction (MGD) in perioperative period.

    Authors: Jinling Ge, Na Liu, Xiaoming Wang, Ying Du, Chaoqing Wang, Zhaorui Li, Jing Li and Lihua Wang
    Citation: BMC Ophthalmology 2020 20:111
  17. To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and predicted lentic...

    Authors: Fang Wu, Houfa Yin, Xinyi Chen and Yabo Yang
    Citation: BMC Ophthalmology 2020 20:110
  18. Macular hole (MH) is a retinal break in the fovea involving partial or complete dehiscence of the neural retinal layers affecting the visual quality by decreasing visual acuity (VA) and visual deformation. We ...

    Authors: Minami Chino, Yuji Yoshikawa, Junji Kanno, Takamitsu Nagashima, Yu Sakaki, Takeshi Katsumoto, Masayuki Shibuya, Takuhei Shoji, Jun Makita and Kei Shinoda
    Citation: BMC Ophthalmology 2020 20:108
  19. To measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis.

    Authors: Yan Zhang, Jianqing Lan, Dan Cao, Cheng Yang, Dawei Yang, Wenjuan Xie and Jin Zeng
    Citation: BMC Ophthalmology 2020 20:107
  20. Blood-retinal barrier cells are known to exhibit a massive phenotypic change during experimental autoimmune uveitis (EAU) development. In an attempt to investigate the mechanisms of blood-retinal barrier (BRB)...

    Authors: Deborah A. Lipski, Vincent Foucart, Rémi Dewispelaere, Laure E. Caspers, Matthieu Defrance, Catherine Bruyns and François Willermain
    Citation: BMC Ophthalmology 2020 20:106

    The Correction to this article has been published in BMC Ophthalmology 2023 23:102

  21. To study the morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia (FDHM) in guinea pigs and explore the possible mechanisms of FDHM formation.

    Authors: Yingxin Zi, Yu Deng, Jingru Zhao, Meiqi Ji, Yali Qin, Tingting Deng and Ming Jin
    Citation: BMC Ophthalmology 2020 20:105
  22. Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that ...

    Authors: Minwen Zhou, Bing Lu, Wei Tan and Mingshui Fu
    Citation: BMC Ophthalmology 2020 20:104
  23. The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma.

    Authors: Tiina Leivo, Johanna Sarmela, Maria Enckell-Aaltonen, Eva Dafgård Kopp, Caroline Schmitt, Peter B. Toft, Haraldur Sigurdsson and Marita Uusitalo
    Citation: BMC Ophthalmology 2020 20:103
  24. In diabetic eyes, various choroidal abnormalities are noted in addition to changes in the retinal circulation, and the risk of increased aqueous flare and retinal thickening after cataract surgery is higher in...

    Authors: Yasuko Ikegami, Miyuki Takahashi and Kana Amino
    Citation: BMC Ophthalmology 2020 20:102
  25. Pseudoduplication of the optic disc is a rare clinical condition that is characterized by a circumscribed, disc-like lesion with radiating vessels but only one normal optic nerve. We report a rare case that in...

    Authors: Liuhui Huang, Qi Zhang, Haiying Jin and Peiquan Zhao
    Citation: BMC Ophthalmology 2020 20:101
  26. The aim of this study was to review the demographic and characteristic distribution data of serious rural pediatric eye injuries in Wenzhou and Changsha, located in Zhejiang Province in East China and Hunan Pr...

    Authors: Chunyan Li, Yaoyao Lin, Haishao Xiao, Huan Lin, Yanyan Chen and Minhui Dai
    Citation: BMC Ophthalmology 2020 20:100
  27. To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation.

    Authors: Ji-Sun Paik, Kyungdo Han, Suk-Woo Yang, Yongkyu Park, Kyungsun Na, Wonkyung Cho, Su-Kyung Jung and Sungeun Kim
    Citation: BMC Ophthalmology 2020 20:99
  28. Systemic lupus erythematosus (SLE) can directly affect various part of the ocular system, but there was no comprehensive analysis of ophthalmic disorders of patients with SLE using population-based data. The a...

    Authors: Chun-Shuo Hsu, Chia-Wen Hsu, Ming-Chi Lu and Malcolm Koo
    Citation: BMC Ophthalmology 2020 20:96
  29. This study aimed to investigate the pre- and post-surgery reading ability in patients with idiopathic epiretinal membrane (ERM) to evaluate whether measurement of reading performance is a helpful test in addit...

    Authors: Hiroki Mieno, Kentaro Kojima, Kazuhito Yoneda, Fumie Kinoshita, Rentaro Mizuno, Shinnosuke Nakaji and Chie Sotozono
    Citation: BMC Ophthalmology 2020 20:95
  30. Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading...

    Authors: Kanae Fukutsu, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Satoru Kase, Kayo Suzuki, Hiroshi Shimizu, Yukiko Shibata, Fumihiko Yamawaki, Masahiro Onozawa and Susumu Ishida
    Citation: BMC Ophthalmology 2020 20:94
  31. Retinoblastoma (RB) is the most frequent pediatric retinal tumor. In the present study, to elucidate chemoresistance mechanisms and identify potential biomarkers in RB, we utilized RNA sequencing (RNAseq) tech...

    Authors: Wen-ping Song, Si Zheng, Hong-juan Yao, Xiao-fei Zhou, Rui Li, Cheng-yue Zhang, Jun-yang Zhao, Lie-wei Wang, Rong-guang Shao and Liang Li
    Citation: BMC Ophthalmology 2020 20:92
  32. To compare vision-related quality of life (VRQOL) between acute and chronic Central serous chorioretinopathy (CSC) and correlate this with Cohen’s Perceived Stress Scale (PSS) questionnaire.

    Authors: Meenakshi Kumar, Elon H. C. van Dijk, Rajiv Raman, Pooja Mehta, Camiel J. F. Boon, Abhilash Goud, Seelam Bharani and Jay Chhablani
    Citation: BMC Ophthalmology 2020 20:90
  33. We aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment.

    Authors: Kana Ikemoto, Shinya Kobayashi, Yu Haranosono, Seiko Kozai, Tomoyuki Wada, Hideki Tokushige and Akio Kawamura
    Citation: BMC Ophthalmology 2020 20:89
  34. To compare the anterior biometrics in eyes with secondary acute angle closure induced by occult lens subluxation (ASAC-LS), misdiagnosed as acute primary angle closure (APAC) at the first visit with APAC, chro...

    Authors: Xiaoli Xing, Liangyu Huang, Fang Tian, Yan Zhang, Yingjuan Lv, Wei Liu and Aihua Liu
    Citation: BMC Ophthalmology 2020 20:87
  35. Postoperative nausea and vomiting (PONV) are common side-effects following strabismus surgery. The present study aimed to compare the effects of different doses of dexmedetomidine (DEX) on PONV incidence in pe...

    Authors: Shuangshuang Li, Tingjie Liu, Junming Xia, Jie Jia and Wenxian Li
    Citation: BMC Ophthalmology 2020 20:86
  36. The aim of this study was to explore the differences in terms of tear film and meibomian glands (MGs) between young Asian soft contact lens (CL) wearers and non-wearers.

    Authors: Tianpu Gu, Lu Zhao, Zhuzhu Liu, Shaozhen Zhao, Hong Nian and Ruihua Wei
    Citation: BMC Ophthalmology 2020 20:84
  37. The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting ...

    Authors: Tianrui He, Yi Zhu and Jibo Zhou
    Citation: BMC Ophthalmology 2020 20:82
  38. Cataract surgery in diabetics is more technically challenging due to a number of factors including poor intraoperative pupil dilation and a higher risk of vision threatening complications. This study evaluates...

    Authors: Marc Labetoulle, Anders Behndig, Marie-José Tassignon, Rudy Nuijts, Rita Mencucci, José Luis Güell, Uwe Pleyer, Jacek Szaflik, Paul Rosen, Alain Bérard, Frédéric Chiambaretta and Béatrice Cochener-Lamard
    Citation: BMC Ophthalmology 2020 20:81
  39. Young adults with type 2 diabetes (aged 18–39 years) are at risk of early onset and rapid progression of diabetic retinopathy, the leading cause of blindness and vision loss in working age adults. Early detect...

    Authors: Amelia J. Lake, Jessica L. Hateley-Browne, Gwyneth Rees and Jane Speight
    Citation: BMC Ophthalmology 2020 20:80
  40. Posterior capsule opacification (PCO) after cataract surgery is influenced by intraocular lens (IOL) design and material. The following is an ex vivo comparison of PCO between the Clareon vs. the AcrySof IOL i...

    Authors: Anna Hillenmayer, Christian M. Wertheimer, Stefan Kassumeh, Annabel von Studnitz, Nikolaus Luft, Andreas Ohlmann, Siegfried Priglinger and Wolfgang J. Mayer
    Citation: BMC Ophthalmology 2020 20:77
  41. The primary aim was to estimate the incidence of primary and secondary childhood glaucoma in Scotland over a 2-year period. The secondary aim was to gauge the confidence and experience of ophthalmologists in S...

    Authors: Daniel Beck, Martin Galea, Cheng Yi Loo, Conrad Schmoll, Frederick R. Burgess, Donald Montgomery and Andrew J. Tatham
    Citation: BMC Ophthalmology 2020 20:76
  42. Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this st...

    Authors: Anita Csorba, Erika Maka, Otto Alexander Maneschg, Attila Szabó, Nóra Szentmáry, Mária Csidey, Miklós Resch, László Imre, Krisztina Knézy and Zoltán Zsolt Nagy
    Citation: BMC Ophthalmology 2020 20:73
  43. To evaluate the safety and efficacy of a treat-and-extend protocol of aflibercept for cystoid macular oedema (CMO) secondary to central retinal vein occlusion (CRVO).

    Authors: Roderick O’Day, Noha Ali, Lyndell L. Lim, Sukhpal Sandhu, Thuy Chau and Sanjeewa Wickremasinghe
    Citation: BMC Ophthalmology 2020 20:69
  44. Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-sm...

    Authors: Aisling B. Mc Glacken-Byrne, David Prentice, Danial Roshandel, Michael R. Brown, Philip Tuch, Kyle S.-Y. Yau, Padma Sivadorai, Mark R. Davis, Nigel G. Laing and Fred K. Chen
    Citation: BMC Ophthalmology 2020 20:68

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