Figure 4
Concentration response curve of VEGF from ET-1 pre-contracted retinal arterioles with extraluminal bevacizumab. In isolated pig retinal arterioles pre-contracted with ET-1 (3 x 10-9 M) VEGF induced a concentration dependent vasodilation response was significantly inhibited by bevacizumab. For ease of comparison the data showing the VEGF induced dilatation in the absence of bevacizumab is also included (grey symbols). * Denotes a significant dilatation compared to contracted baseline (p < 0.05).