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  1. Research article

    Switch to aflibercept or ranibizumab after initial treatment with bevacizumab in eyes with neovascular AMD

    To evaluate changes in central macular thickness (CMT) and visual outcome in patients with neovascular age-related macular degeneration (AMD) treated initially with bevacizumab and subsequently switched to eit...

    Maria Waizel, Margarita G. Todorova, Michael Masyk, Katharina Wolf, Annekatrin Rickmann, Khaled Helaiwa, Björn R. Blanke and Peter Szurman

    BMC Ophthalmology 2017 17:79

    Published on: 23 May 2017

  2. Research article

    Next-generation sequencing for D47N mutation in Cx50 analysis associated with autosomal dominant congenital cataract in a six-generation Chinese family

    Congenital cataract is the most frequent cause of blindness during infancy or early childhood. To date, more than 40 loci associated with congenital cataract have been identified, including at least 26 genes o...

    Chao Shen, Jingbing Wang, Xiaotang Wu, Fuchao Wang, Yang Liu, Xiaoying Guo, Lina Zhang, Yanfei Cao, Xiuhua Cao and Hongxing Ma

    BMC Ophthalmology 2017 17:73

    Published on: 19 May 2017

  3. Research article

    Construction and implications of structural equation modeling network for pediatric cataract: a data mining research of rare diseases

    The majority of rare diseases are complex diseases caused by a combination of multiple morbigenous factors. However, uncovering the complex etiology and pathogenesis of rare diseases is difficult due to limite...

    Erping Long, Shuangjuan Xu, Zhenzhen Liu, Xiaohang Wu, Xiayin Zhang, Jinghui Wang, Wangting Li, Runzhong Liu, Zicong Chen, Kexin Chen, Tongyong Yu, Dongxuan Wu, Xutu Zhao, Jingjing Chen, Zhuoling Lin, Qianzhong Cao…

    BMC Ophthalmology 2017 17:74

    Published on: 19 May 2017

  4. Research article

    A computerized red glass test for quantifying diplopia

    Accurate evaluation of diplopia during bedside physical examination is challenging. We developed a new computerized red glass test (CRT) to detect, localize, and quantify diplopia and investigated whether the ...

    Han Soo Yoo, Eunjeong Park, Soolienah Rhiu, Hyuk-Jae Chang, Kyoungsub Kim, Joonsang Yoo, Ji Hoe Heo and Hyo Suk Nam

    BMC Ophthalmology 2017 17:71

    Published on: 17 May 2017

  5. Research article

    Short term visual outcomes of a new trifocal intraocular lens

    Today, patients often expect to achieve spectacle independance after cataract surgery. New trifocal intraocular lenses have been developed to try and fullfill this demand. The purpose of this study is to repor...

    Jorge L. García-Pérez, Juan Gros-Otero, Celia Sánchez-Ramos, Vanesa Blázquez and Inés Contreras

    BMC Ophthalmology 2017 17:72

    Published on: 17 May 2017

  6. Research article

    Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration

    To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photorec...

    Helena Giannakaki-Zimmermann, Giuseppe Querques, Inger Christine Munch, Daraius Shroff, David Sarraf, Xuejing Chen, Eduardo Cunha-Souza, Sarah Mrejen, Vittorio Capuano, Murilo W. Rodrigues, Charu Gupta, Andreas Ebneter, Martin S. Zinkernagel and Marion R. Munk

    BMC Ophthalmology 2017 17:67

    Published on: 15 May 2017

  7. Case report

    Case of asteroid hyalosis that developed severely reduced vision after cataract surgery

    To report our findings in a patient with asteroid hyalosis (AH) who had a severe reduction of his visual acuity following cataract surgery. The vision was improved by vitreous surgery.

    Ryosuke Ochi, Bumpei Sato, Seita Morishita, Yukihiro Imagawa, Masashi Mimura, Masanori Fukumoto, Takaki Sato, Takatoshi Kobayashi, Teruyo Kida and Tsunehiko Ikeda

    BMC Ophthalmology 2017 17:68

    Published on: 15 May 2017

  8. Research article

    Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study

    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ...

    Loraine L. W. Chow, Kendrick C. Shih, Johnny C. Y. Chan, Jimmy S. M. Lai and Alex L. K. Ng

    BMC Ophthalmology 2017 17:65

    Published on: 12 May 2017

  9. Research article

    Effect of Limbal relaxing incisions during implantable collamer lens surgery

    The limbal relaxing incisions (LRIs) technique is a safe and an inexpensive procedure, which is simple for experts to perform. It can effectively reduce astigmatism and result in a rapid visual rehabilitation....

    Zhen Li, Yu Han, Budan Hu, Huibin Du, Gengsheng Hao and Xiaoxi Chen

    BMC Ophthalmology 2017 17:63

    Published on: 8 May 2017

  10. Research article

    24-month clinical outcomes of a treat-and-extend regimen with ranibizumab for wet age-related macular degeneration in a real life setting

    To evaluate the clinical effectiveness and analyze the outcomes of a treat-and-extend (T&E) treatment regimen with ranibizumab for wet age-related macular degeneration (ARMD) in real life clinical settings ove...

    Athanasios Vardarinos, Nitin Gupta, Raazia Janjua, Abigail Iron, Theo Empeslidis and Konstantinos T. Tsaousis

    BMC Ophthalmology 2017 17:58

    Published on: 27 April 2017

  11. Research article

    Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study

    To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography.

    Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura and Masaru Inatani

    BMC Ophthalmology 2017 17:57

    Published on: 26 April 2017

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