From: Ocular transient receptor potential channel function in health and disease
Name | Selectivity PCa:PNa [12] | Activation threshold temperature (°C) [30] | Posterior eye section | Anterior eye section | ||
---|---|---|---|---|---|---|
TRPC1 | Non-selective | --- | Store depletion, 2-APB | Component of SOC | ||
TRPC2 | 2.7 | --- | DAG | ? | TM [121] | |
TRPC3 | 1.6 | --- | Store depletion, OAG, 2-APB, DAG, Pyr3 | Component of SOC | ||
TRPC4 | 1.1–9.0 | --- | Store depletion 2-APB | Component of SOC | HCEC [60] | |
TRPV1 | 4–10 | >43 | Capsaicin, capsazepine, anandamide, NADA | Heat sensor osmosensora | Rat retina [49], human retina (tumor) [57], uvea (tumor) [59], human RPE [58, 59] | |
TRPV2 | 1–3 | >52 | Cannabidiol, 2-APB | Heat sensor | Human RPE [58] | HCEC-12 [88] |
TRPV3 | 2,6 | 30–39 | Camphor, 2-APB | Moderate heat sensor | Human RPE [58] | |
TRPV4 | 6–10 | 24–27 | 4α-PDD, GSK 1016790A | Moderate heat sensor osmosensorb | ||
TRPM1 | Not determed | --- | mGluR6 | Transduction of light signals | --- | |
TRPM2 | 0.5–1.6 |  | H2O2, ADP-ribose, β-NAD+ | Mechanotransduction | --- | |
TRPM7 | 3 | --- | Spermine | Â | --- | |
TRPM8 | 1–3.3 | <23–28 | Menthol, icilin, eucalyptol, BCTC | Moderate cold sensor | ||
TRPA1 | 0,8 | <17 | Icilin, alicin | Cold sensor |