Fig. 1
Expression of dnMAML1 led to irreversible loss of goblet cells. TC/RosaLSL-dnMAML1 (OSwt) (a) and K14-rtTA/TC/RosaLSL-dnMAML1 (OSLSL-dnMAML1) (b) which had been fed with Dox from P0 to P16 and then changed to regular chow from P17 to P180. Eye photographs (a,b) were taken on P180. Noticed that severe ocular surface ulceration was observed in Noted that severe ocular surface ulceration was observed in OSdnMAML1 (compare b to a). Histological examinations on paraffin sections (c, C 1 , d, D 1 , D 2 ) demonstrated that OSdnMAML1 (compare d to c ) led to persistent corneal edema, and neovascularization (D 1 ) and conjunctival squamous hyperplasia (D 2 ). Abbreviations: bv, blood vessel; cjs, conjunctival sac. (Courtesy of Development)