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Table 4 Genotype and allele frequencies of MTHFR (C677T) variants in POAG patients and matched controls

From: Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population

Genotype/allele

POAG (N = 144)

Control (280)

P- value

RR

EFb/PF

N

%

N

%

CC

88

61.11

210

75.00

0.003a

0.52

0.214

CT

56

38.89

70

25.00

0.003a

1.91

0.211b

TT

0

-

0

-

-

-

-

C-allele

232

80.56

490

87.50

0.008a

0.59

0.182

T-allele

56

19.44

70

12.50

0.008a

1.69

0.181b

  1. N number of subjects, EF etiological fraction, PF preventive fraction
  2. astatistically significant
  3. bdata for EF