Tracing the natural course of visual acuity and quality of life in neovascular age-related macular degeneration: a systematic review and quality of life study

Table 1 Studies describing visual acuity loss secondary to neovascular age-related macular degeneration

Study	Design	Follow-up (months)	Eyes	Baseline VA (ETDRS)	Horizontal translation factor (months)
Study	Design	Follow-up (months)	Eyes	Baseline VA (ETDRS)	Lesion-specific analysis	Combined analysis
Occult lesions
Arnold [15]	RCT	38	29	60.3	15.85	17.7
Blinder - TAP & VIP studies [16]	RCT	24	92	65.2	14.38	15.5
Boyer - MARINA study [17]	RCT	24	151	53.6	21.63	23.0
Bressler [18]	OCS	36	84	55	21.52	22.3
Bressler - MPS study [19]	RS	60	26	65	13.31	14.6
Cardillo-Piccolino [20]	OCS	20	63	65.1	11.70	12.8
Eter [21]	RCT	6	15	58.2	18.32	19.5
Gragoudas - VISION study [22]	RCT	12	120	52.7	24.77	25.4
Gustavsson [23]	RCT	12	9	45	40.46	36.9
Jaakkola [24]	RCT	36	45	52.5	29.87	28.6
Kaiser - VIO study [25]	RCT	24	120	55.7	21.26	22.4
Kobayashi [26]	RCT	24	7	59.9	16.12	17.9
Krebs [27]	OCS	3	107	67	10.46	11.9
Myint [28]	RCT	12	11	50.5	24.38	26.6
Pece [29]	OCS	13.5	383	66.9	10.29	11.5
Soubrane [30]	RS	34	82	69.9	8.42	9.5
Tholen [31]	RCT	24	21	66.2	11.86	13.1
Minimally classic lesions
Bressler - VIM study [32]	RCT	24	40	54.5	5.49	24.42
Blinder - TAP & VIP studies [16]	RCT	24	104	53.7	6.22	23.43
Gragoudas - VISION study [22]	RCT	12	102	52.7	6.41	25.10
Schneider [33]	RS	8.3	4	41.3	20.74	41.99
Boyer - MARINA study [17]	RCT	24	87	53.6	6.04	23.43
Predominantly classic lesions
D’Amico - AA study [34, 35]	RCT	24	30	47	6.35	35.24
Blinder - TAP & VIP studies [16]	RCT	24	83	50.6	5.60	35.14
Bressler - MPS study [19]	RS	60	119	59.7	3.15	23.51
Gragoudas - VISION study [22]	RCT	12	76	52.7	4.59	25.40
MPS study [36]	RS	42	184	45	7.89	40.82
Mandai [37]	RCT	36	4	44.7	7.53	32.85
Valmaggia [38]	RCT	18	29	42.5	7.68	37.90
Behrendt [39]	RCT	12	66	58	3.17	23.85

ETDRS, Early Treatment Diabetic Retinopathy Study, OCS observational case series, RCT randomized controlled trial, RS retrospective study, VA visual acuity

ISSN: 1471-2415