Time point\Group | Placebo | 0.1% loading dosea | 0.01%b |
---|---|---|---|
AL, mm | |||
Baseline | 24.60 (24.35; 24.86) | ||
9-mo | 24.88 (24.56; 25.20) | −0.11 (− 0.17; −0.04) | −0.07 (− 0.13; 0.00) |
12-mo | 24.94 (24.62; 25.26) | −0.10 (− 0.17; −0.02) | −0.07 (− 0.15; 0.00) |
12-mo adjusted-p | 0.06 | 0.16 | |
SER, diopters | |||
Baseline | −2.99 (− 3.37; −2.60) | ||
9-mo | −3.57 (− 4.11; −3.03) | 0.35 (0.17; 0.52) | 0.18 (0.00; 0.35) |
12-mo | −3.64 (− 4.19; −3.09) | 0.24 (0.05; 0.42) | 0.19 (0.00; 0.38) |
12-mo adjusted-p | 0.06 | 0.14 | |
IOP, mmHg | |||
Baseline | 16.1 (15.3; 17.0) | ||
9-mo | 16.7 (14.6; 18.9) | -0.3 (-1.8; 1.2) | -0.7 (-2.2; 0.8) |
12-mo | 16.6 (14.5; 18.8) | 0.2 (-1.3; 1.7) | 0.0 (-1.5; 1.5) |
12-mo adjusted-p | 0.88 | 0.98 | |
Distance BCVA, LogMAR | |||
Baseline | −0.10 (− 0.12; −0.09) | ||
9-mo | −0.11 (− 0.15; −0.07) | −0.01 (− 0.03; 0.01) | 0.01 (− 0.01; 0.04) |
12-mo | −0.12 (− 0.16; −0.08) | −0.02 (− 0.04; 0.01) | −0.00 (− 0.03; 0.02) |
12-mo adjusted-p | 0.42 | 0.88 | |
Near BCVA, LogMAR | |||
Baseline | −0.07 (− 0.09; −0.05) | ||
9-mo | −0.06 (− 0.12; −0.01) | −0.02 (− 0.06; 0.02) | 0.00 (− 0.04; 0.04) |
12-mo | −0.09 (− 0.14; −0.04) | −0.01 (− 0.04; 0.02) | 0.01 (− 0.02; 0.04) |
12-mo adjusted-p | 0.78 | 0.52 | |
Accommodation amplitude, diopters | |||
Baseline | 16.4 (15.3; 17.5) | ||
9-mo | 15.4 (12.9; 17.0) | −0.8 (− 2.2; 0.6) | −0.2 (− 1.6; 1.2) |
12-mo | 16.1 (14.2; 19.1) | −0.7 (− 2.2; 0.8) | −1.0 (− 2.5; 0.5) |
12-mo adjusted-p | 0.52 | 0.32 | |
Mesopic pupil diameter, mm | |||
Baseline | 4.14 (3.92; 4.36) | ||
9-mo | 4.07 (3.59; 4.55) | 0.31 (0.01; 0.62) | 0.54 (0.24; 0.85) |
12-mo | 4.10 (3.62; 4.57) | 0.43 (0.13; 0.72) | 0.51 (0.21; 0.80) |
12-mo adjusted-p | 0.02* | 0.006* | |
Photopic pupil diameter, mm | |||
Baseline | 2.71 (2.61; 2.81) | ||
9-mo | 2.67 (2.46; 2.89) | 0.21 (0.08; 0.35) | 0.23 (0.10; 0.36) |
12-mo | 2.67 (2.45; 2.89) | 0.18 (0.04; 0.33) | 0.22 (0.08; 0.36) |
12-mo adjusted-p | 0.05* | 0.01* |