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Table 1 Demographic summary of all the studies included in the systematic review and meta-analysis

From: Systematic review and meta-analysis of mass spectrometry proteomics applied to ocular fluids to assess potential biomarkers of age-related macular degeneration

First author

Year

Type of studies

AMD

Controls

Ref

n

Age

Gender(m/f)

n

Age

Gender(m/f)

Batya Rinsky

2021

Observational studies

30

dry AMD: 77.3 ± 10.5,

wet AMD: 78.6 ± 7.4,

dry AMD: 10/5

wet AMD: 6/9

20

74.8 ± 7.1

10/10

[21]

Je-Hyun Baek

2018

Observational studies

4

73.5 ± 4.9

0/4

2

73.5 ± 4.9

0/2

[22]

Tae Wan Kim

2012

Observational studies

9

68.9 ± 12.8

5/4

8

73.0 ± 11.4

4/4

[23]

Ching-Yao Tsai

2022

RCT

28

/

/

25

/

/

[24]

Si-Chang Qu

2019

Observational studies

12

80.82 ± 4.17

5/7

12

68.81 ± 18.82

6/6

[25]

Jiaqi Yao

2013

Observational studies

6

56.17 ± 9.28

3/3

6

57.5 ± 2.95

3/3

[26]

Gum-Yong Kang

2014

RCT

14

69.9 ± 7.4

9/5

18

67.3 ± 6.8

5/1

[27]

Hyungwoo Lee

2014

RCT

15

69.8 ± 7.2

8/7

15

70.3 ± 8.0

8/7

[28]

Matthias Nobl

2016

Observational studies

72

76.5 ± 10.0

28/44

16

61.7 ± 11.7

7/9

[29]

Michael Janusz Koss

2014

Observational studies

73

77.8

23/50

15

60.0 ± 16.0

7/8

[30]

Christian Schori

2018

Observational studies

16

dry AMD: 80.3 ± 6.6

wet AMD: 80.8 ± 6.2

5/11

9

70.1 ± 4.1

4/5

[31]

  1. AMD Age-related macular degeneration, m/f male/female, Ref References, RCT Randomized controlled trial