Table 2 Proteomic studies of AMD and biomarkers discovery using MS-based method in human intraocular fluids

Batya Rinsky

(2021)

15 wet AMD

15 dry AMD

20 controls

Aqueous

humor

pooled

label-free

ELISA

label-free

Yes/No

AMD vs. Controls:

↑ P10909; P29622; P18065;

Q9NPH3; P02753;

P00746; P02741; Q9UGM5

↓ P13726

dry AMD vs. wet AMD:

↑P10909; P29622; P13726

[21]

Je-Hyun Baek(2018)

4 dry AMD2 controls

Aqueous humor

individuated

LC–MS/MS

ELISA

SWATH-MS

Yes/No

AMD vs. Controls:

↑P02647; P06727; P29622;

P51884; O60938; P02647;

29,622;

P51884; O60938; P10909

↓P36980; P10909; P36955;

P41222; P01033; P06727;

36,980; P07339;

P36955; P41222; P01033

[22]

Tae Wan Kim (2012)

9 AMD 8 controls

Aqueous humor

individuated

LC–ESI–MS/MS

/

MRM

Yes/No

AMD vs Controls:

↑ P00450; P36955; P05155; Q15582;

P10909; P07339; P01034

[23]

Ching-Yao Tsai (2022)

28 AMD 25 controls

Aqueous humor

pooled

LC–MS/MS

/

MS

No/No

AMD vs Controls:

↑P02647; Q6MZU6; Q9UBM4;

P10909; P01024;

↓P41222

[24]

Si-Chang Qu (2019)

12 dry AMD 12 controls

Aqueous humor

pooled

LC–MS/MS

ELISA Western Blot

iTRAQ

No/No

AMD vs Controls:

↑ P05109; Q14118; P01876 P02763;P06727; P07451

; P02788; P30838; P01042; P63261;

P19823; P02647; P19652; P07225;

P25311; P43652 P80748; P00338;

P01024; P02750; P02760; P02675;

P04196; P00734; P00747; P05546;

P61626; P04406; P01775; P00751;

P10451; P01023; P35749; P02774;

P31025; P01861; P01772; Q9HCQ7;

↓ P49788; O95967; Q9BRK5; P13591;

P03950; P23142; P01779; Q13510;

P11021; P06309; O00391; Q92563;

P61812; Q16270; P00738; Q8N475;

P28799; Q96KN2; P30041; Q15113;

P51693; P02452; Q06481; P16035;

Q16568; O15031; P35555; Q8WXD2;

P02766; P22352; Q02809;

P06865; Q99435; P01034; P05154;

Q12907;P06396; P13645; P07339;

P16870; Q9HCB6; P39060; P04264;

Q92520; P07477; Q12805;

13,822;

P10745; P41222; Q9BU40; O15537

[25]

Jiaqi Yao (2013)

6 wet AMD6 controls

Aqueous humor

pooled

MALDI TOF/TOF MS

ELISA

2-DE

No/No

AMD vs Controls: ↑P31025

[26]

Gum-Yong Kang (2014)

26 wet AMD18 Controls

Aqueous humor

pooled

LC–ESI–MS/MS

Western Blot

LC-MRM

No/No

AMD vs Controls: ↑ P62736; P35579; P07339;

P05787; P02533; P34932

[27]

Hyungwoo Lee (2014)

15 AMD15 controls

Aqueous humor

pooled

LC–ESI–MS/MS

Western blot

LC-MRM

No/No

AMD vs Controls: ↑P04844

[28]

Matthias Nobl (2016)

72 wet AMD16 controls

Vitreous humor

individuated

LC–MS/MS

ELISA

MS

No/No

AMD vs Controls:

↑ P10909; P36955; P41222;

P02787; Q8WZ42; P01834;

P0CG05; B9A064; P01857;

↓ Q02388; Q9UBM4

P02489; Q5VST9

[29]

Michael Janusz Koss (2014)

73 AMD

15 controls

Vitreous humor

individuated

LC–MS/MS

Western blot

MS

No/No

AMD vs Controls:

↑P01871; P02768; P01857;

P01008; P01859; P02787;

P43652; P04196; P02753;

P02647; P02671; P01876;

P02765; P02766; P41222;

P00738; P22352; P01009

[30]

Christian Schori (2018)

6 dry AMD10 wet AMD9 controls

Vitreous humor

pooled

LC–MS/MS

ELISA

label-free

Yes/Yes

AMD vs Controls:

↑ P13716; P07998; Q9H3G5; P06276; P00390;

P17948; Q04917; P00352;

Q6NS36; P13284; P36222;

Q99497; O00187; P15259

[31]