Characteristics | Baseline | 1Â m | 3Â m | P-value |
---|---|---|---|---|
Ocular symptoms | ||||
OSDI (score) - mean (SD) | 38.65 ± 17.93 | 24.06 ± 12.33 | 18.80 ± 11.75 | <0.01 |
Severe (33–100) - n (%) | 8 (27%) | 9 (30%) | 6 (20%) |  |
Moderate (23–32) - n (%) | 4 (13%) | 6 (20%) | 5 (17%) |  |
Mild (13–22) - n (%) | 18 (60%) | 9 (30%) | 13 (43%) |  |
No dry eye symptom (0–12) - n (%) | 0 (0%) | 6 (20%) | 6 (20%) |  |
NRS (score) - median (Q1, Q3) | 3 (2, 5.5) | 2 (2, 3.25) | 2 (0, 2) | <0.01 |
Severe pain (7–10) - n (%) | 7 (23%) | 2 (7%) | 1 (3%) |  |
Moderate pain (4–6) - n (%) | 6 (20%) | 5 (17%) | 1 (3%) |  |
Mild pain (1–3) - n (%) | 17 (57%) | 19 (63%) | 19 (63%) |  |
No pain (0) - n (%) | 0 (0%) | 4 (13%) | 9 (30%) | Â |
NPSI-Eye (score) - mean (SD) | 5.23 ± 10.76 | 2.50 ± 7.23 | 0.02 ± 0.10 | 0.02 |
Burning spontaneous pain | 0.83 ± 1.89 | 0.25 ± 0.71 | 0.02 ± 0.10 | 0.04 |
Pressing spontaneous pain | 0.46 ± 1.09 | 0.33 ± 0.86 | 0.04 ± 0.20 | 0.05 |
Paroxysmal pain | 0.11 ± 0.31 | 0.13 ± 0.56 | 0.02 ± 0.10 | 0.08 |
Evoked pain | 0.79 ± 1.88 | 0.35 ± 1.08 | 0.05 ± 0.02 | 0.03 |
Paresthesia/dysesthesia | 0.43 ± 1.25 | 0.15 ± 0.67 | 0.04 ± 0.20 | 0.21 |
Ocular signs | ||||
TBUT (s) - mean (SD) | 3.90 ± 2.92 | 6.10 ± 3.37 | 6.68 ± 2.95 | <0.01 |
CFS (score) - median (Q1, Q3) | 3.00 (0, 5) | 0 (0, 1) | 0 (0, 0.5) | <0.01 |
LG (score) - median (Q1, Q3) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0.11 |
Schirmer I test (mm) - mean (SD) | 13.73 ± 9.33 | 17.25 ± 10.02 | 18.28 ± 7.98 | <0.01 |
Corneal nerve parameters- mean (SD) | ||||
Corneal sensitivity (cm) | 5.77 ± 0.41 | 5.93 ± 0.13 | 5.99 ± 0.02 | <0.01 |
CNFD (n/mm2) | 20.66 ± 9.14 | 20.90 ± 8.37 | 20.27 ± 7.85 | 0.76 |
CNBD (n/mm2) | 46.83 ± 33.51 | 43.25 ± 31.16 | 39.13 ± 31.65 | 0.22 |
CNFL (mm/mm2) | 15.93 ± 5.10 | 15.07 ± 4.66 | 15.06 ± 4.21 | 0.18 |
CTBD (n/mm2) | 83.02 ± 53.32 | 70.62 ± 44.51 | 68.14 ± 46.25 | 0.15 |
CNFW (mm /mm2) | 0.021 ± 0.00 | 0.022 ± 0.00 | 0.022 ± 0.00 | 0.69 |