Genetic variants in the FOXO1 and ZNF469 genes are associated with keratoconus in Sweden: a case-control study

Table 2 Summary for the genetic analysis

Gene: SNP	Genotype	Cases	Controls	OR (95% CI)^add	p^add	OR (95% CI)^dom	p^dom
Gene: SNP	n (%)	n (%)	Controls	OR (95% CI)^add	p^add	OR (95% CI)^dom	p^dom
FOXO1:rs2721051	AA	4 (2.5)	11 (2.7)	1.90 (1.27–2.40)	0.002*	2.32 (1.44–3.74)	0.005
	AG	44 (27.2)	56 (13.9)
	GG	114 (70.4)	337 (83.4)
BANP-ZNF469:rs9938149	CC	15 (9.3)	42 (10.4)	0.66 (0.48–0.89)	0.008	0.53 (0.35–0.79)	0.002*
	CA	56 (34.8)	201 (49.8)
	AA	90 (55.9)	161 (39.9)
COL5A1:rs7044529	TT	2 (1.2)	7 (1.7)	1.19 (0.81–1.75)	0.4	1.28 (0.84–1.95)	0.2
	TC	56 (34.8)	111 (27.4)
	CC	103 (64.0)	287 (70.9)
RXRA-COL5A1:rs1536482	AA	16 (9.9)	42 (10.4)	1.14 (0.84–1.54)	0.4	1.16 (0.78–1.73)	0.5
	AG	70 (43.2)	154 (38.0)
	GG	76 (46.9)	209 (51.6)
FINDC3B:rs4894535	TT	6 (3.7)	15 (3.7)	0.75 (0.52–1.08)	0.1	0.68 (0.45–1.04)	0.07
	TC	45 (27.6)	130 (32.0)
	CC	112 (68.7)	261 (64.3)
RAB3GAP1:rs4954218	GG	11 (6.8)	38 (9.4)	0.88 (0.64–1.19)	0.4	0.88 (0.59–1.31) 0.5	0.5
	GT	64 (39.6)	169 (41.9)
	TT	87 (53.7)	196 (48.6)
HGF:rs2286194	AA	7 (4.3)	12 (3.0)	1.13 (0.64–1.19)	0.5	1.14 (0.75–1.74) 0.5	0.5
	TA	47 (29.2)	110 (27.1)
	TT	107 (66.5)	284 (70.0)
HGF:rs3735520	AA	31 (19.4)	83 (20.4)	0.96 (0.73–1.28)	0.8	0.93 (0.61–1.42)	0.7
	GA	77 (48.1)	197 (48.5)
	GG	52 (32.5)	126 (31.0)
HGF:rs17501108	TT	1 (0.6)	9 (2.2)	0.69 (0.45–1.06)	0.09	0.71 (0.44–1.13) 0.2	0.2
	TG	33 (20.5)	94 (23.3)
	GG	127 (78.9)	301 (74.5)
LOX:rs2956540	GG	33 (20.2)	90 (22.4)	0.82 (0.62–1.07)	0.1	0.78 (0.51–1.20)	0.3
	GC	75 (46.0)	197 (49.0)
	CC	55 (33.7)	115 (28.6)
LOX:rs10519694	TT	10 (6.2)	35 (8.6)	0.80 (0.58–1.09)	0.2	0.80 (0.54–1.19)	0.3
	TC	64 (39.5)	166 (40.9)
	CC	88 (54.3)	205 (50.5)

SNP, single nucleotide polymorphism; n, numbers; OR, Odds Ratio; add, additive genetic model (i.e. rare genotypes are coded as 2, heterozygotes coded as 1, and common genotypes coded as 0); dom, dominant genetic model (i. e. rare genotypes and heterozygotes are coded as 1, and common genotypes coded as 0). Significant p-values are shown in bold. A p-value < 0.05 was considered significant. Results are based on logistic regression models adjusted for sex. *p-values surviving Bonferroni correction for multiple testing based on 11 independent tests

ISSN: 1471-2415