Table 1 Comparison between previously reported cases of Candida glabrata endophthalmitis following penetrating keratoplasty
Author/Year | Age/Gender | Indication for PK | Onset of endophthalmitis | Culture | Treatment | Side effects |
|---|---|---|---|---|---|---|
Larsen PA et al, 1978 | 76/Female | Aphakic bullous keratopathy | 48 days | Positive (donor rim and fluid) | Topical and intravenous amphotericin B, oral and topical flucytosine | Renal toxicity; death |
Cameron JA et al, 1991 | 22/Male | Keratoconus | 7 days | Positive (donor rim) | Intravitreal amphotericin B, subconjunctival miconazole, topical natamycin,oral flucytocine | Not stated |
Antonios et al, 1991 | 30/Male | Cornea scar | 11 days | Positive (donor rim) | Not stated | Not stated |
Cameron JA et al, 1998 | 46/Male | Cornea scar | 3 weeks | Positive (donor rim) | Not stated | Not stated |
Chapman FM et al, 1998 | 43/Male | Keratoconus | 4 days | Positive (transport medium) | Topical,intracameral and subconjunctival amphotericin B | Nil |
Garcia-Valenzuela E et al, 2005 | 85/Female | Fuch's endothelial dystrophy, pseudophakia | 5 months | Positive (donor rim) | Oral fluconazole, intravitreal and intrastromal amphotericin B, | Not stated |
Keyhani et al, 2005 | 82/Female | Pseudophakia corneal oedema | 1st to 2nd week | Positive (donor rim) | Not stated | Not stated |
Grueb M et al, 2006 | 26/Male | Keratoconus | 10 hours | Positive (transport medium) | Systemic fluconazole, Topical and intracameral amphotericin B | Nil |
Al Assiri A et al, 2006 | 69/Male | Trachomatous scarring | 5 months | Positive (donor rim) | Topical and intracameral amphotericin B, systemic fluconazole | Not stated |
Caldwell MC et al, 2009 | 57/Male | Post LASIK keratectasia | 10 days | Positive (donor rim) | Oral fluconazole, intravitreal and topical amphotericin B, topical and oral voriconazole | Liver toxicity |
Tappeiner C et al, 2009 | 70/Female | Fuch's endothelial dystrophy | 1 day | Positive (donor rim) | Oral fluconazole, topical and subconjunctival amphotericin B, intravenous liposomal amphotericin B and intravenous caspofungin | Not stated |
Tappeiner C et al, 2009 | 53/not stated | Fuch's endothelial dystrophy | 1 day | Positive (donor rim) | Oral fluconazole and voriconazole; intracameral and subconjunctival Amphotericin B, intravenous liposomal amphotericin B and intravenous caspofungin | Renal toxicity |
Current study | 63/Male | Fuch's endothelial dystrophy | 2 weeks | Negative (donor rim and transport medium) Positive (recipient AC and vitreous tap culture) | Topical, intravenous, intravitreal and intracameral amphotericin B | Nil |