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  1. Endogenous endophthalmitis is an infection of the eye secondary to sepsis, occurring in 0.04–0.5% of bacteremia or fungemia. Risk factors include intravenous drug abuse (IVDA), diabetes, indwelling catheters, ...

    Authors: Kathleen A. Regan, Nila S. Radhakrishnan, Jon D. Hammer, Benjamin D. Wilson, Lara Beth Gadkowski and Siva S. R. Iyer

    Citation: BMC Ophthalmology 2020 20:138

    Content type: Research article

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  2. Limited data is available on retinal vessel morphology in the north China. The study aimed to evaluate the prevalence of retinal vascular abnormalities (RVAs) and investigate their associations with the self-r...

    Authors: Junwei Wang, Fei Leng, Zhijian Li, Xianling Tang, Hua Qian, Xiaoguang Li, Yi Zhang, Xuedong Chen, Haitao Du and Ping Liu

    Citation: BMC Ophthalmology 2020 20:136

    Content type: Research article

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  3. Inflammation of RPE cells led to different kinds of eye diseases and affected the normal function of the retina. Furthermore, higher levels of ROCK1 and ROCK2 induced injury of endothelial cells and many infla...

    Authors: Zhao Gao, Qiang Li, Yunda Zhang, Xiaohong Gao, Haiyan Li and Zhigang Yuan

    Citation: BMC Ophthalmology 2020 20:134

    Content type: Research article

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  4. Bullous serous retinal detachment (RD) with retinal pigment epithelial (RPE) tear is a rare and severe variant of chronic central serous chorioretinopathy (CSC). Due to its atypical presentation, it may raise ...

    Authors: Emilia Maggio, Maurizio Mete, Giorgia Maraone, Fabrizio Arena and Grazia Pertile

    Citation: BMC Ophthalmology 2020 20:133

    Content type: Case report

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  5. Evidence-based criteria for the treatment of autoimmune retinopathy (AIR) have not been established. The pathology and clinical features of each antibody causing AIR, and its long-term course are still undeter...

    Authors: Gen Miura, Takayuki Baba, Takehito Iwase, Hisao Ohde, Atsuhiro Kanda, Wataru Saito, Susumu Ishida and Shuichi Yamamoto

    Citation: BMC Ophthalmology 2020 20:132

    Content type: Case report

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  6. To compare efficacy and safety of intravitreal aflibercept (IVA) injection with panretinal photocoagulation (PRP) versus early vitrectomy for diabetic vitreous hemorrhage (VH).

    Authors: Ahmed Hosni Abd Elhamid, Ahmed Abd El Alim Mohamed and Abeer Mohamed Khattab

    Citation: BMC Ophthalmology 2020 20:130

    Content type: Research article

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  7. We aimed to compare the intraocular pressure (IOP) measurements by a dynamic Scheimpflug analyzer (Corvis ST), a non-contact tonometer, and an ocular response analyzer after hyperopic small-incision lenticule ...

    Authors: Dan Fu, Meiyan Li, Michael C. Knorz, Shengsheng Wei, Jianmin Shang and Xingtao Zhou

    Citation: BMC Ophthalmology 2020 20:129

    Content type: Research article

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  8. Group B streptococcus (GBS), a gram-positive coccus that occasionally causes neonatal sepsis or invasive infection in the elderly, has been considered a rare cause of endogenous bacterial endophthalmitis (EBE)...

    Authors: Masaaki Yoshida, Shunji Yokokura, Takashi Nishida, Kiyofumi Mochizuki, Takashi Suzuki, Kazuichi Maruyama, Takaaki Otomo, Koji M. Nishiguchi, Hiroshi Kunikata and Toru Nakazawa

    Citation: BMC Ophthalmology 2020 20:126

    Content type: Research article

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  9. Outcome measurements currently used in chronic uveitis care fail to cover the full patient perspective. The aim of this study is to develop a conceptual model of the factors that adult patients with chronic uv...

    Authors: Aline C. Stolk-Vos, Hamasa Kasigar, Karlijn J. Nijmeijer, Tom O. Missotten, Jan J. Busschbach, Joris J. van de Klundert and Leonieke W. Kranenburg

    Citation: BMC Ophthalmology 2020 20:125

    Content type: Research article

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  10. Eye infection is a public health problem in developing countries including Ethiopia. Bacteria are major causative agents of eye infections that can lead to loss of vision. The objective of this study was to de...

    Authors: Ahmed Adem Mohammed, Musa Mohammed Ali and Mengistu Hailemariam Zenebe

    Citation: BMC Ophthalmology 2020 20:124

    Content type: Research article

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  11. Several previous studies reported a greater prevalence of dry eye syndrome (DES) among patients with psychiatric diseases. The aim of this study is to investigate the prevalence and risk factors of DES in pati...

    Authors: Chiao-Ying Liang, Wai-Man Cheang, Chun-Yuan Wang, Keng-Hung Lin, Li-Chen Wei, Yu-Yen Chen and Ying-Cheng Shen

    Citation: BMC Ophthalmology 2020 20:123

    Content type: Research article

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  12. Intravitreal injections are a mandatory treatment for macular edema due to nAMD, DME and RVO. These chronic diseases usually need chronic treatment using intravitreal injections with anti-VEGF agents. Thus, ma...

    Authors: Ingo Volkmann, Katharina Knoll, Mareile Wiezorrek, Oliver Greb and Carsten Framme

    Citation: BMC Ophthalmology 2020 20:122

    Content type: Research article

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  13. Pupillary evaluation is a crucial element of physical exams. Noting size, reactivity, and consensual response is critical in assessing for optic nerve dysfunction. We aim to establish normative data for scotop...

    Authors: Sanket S. Shah, Hantamalala Ralay Ranaivo, Rebecca B. Mets-Halgrimson, Karen Rychlik and Sudhi P. Kurup

    Citation: BMC Ophthalmology 2020 20:121

    Content type: Research article

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  14. The cellular process of autophagy is essential for maintaining the health of ocular tissue. Dysregulation of autophagy is associated with several ocular diseases including keratoconus and macular degeneration....

    Authors: Kimberly M. Brothers, Nicholas A. Stella and Robert M. Q. Shanks

    Citation: BMC Ophthalmology 2020 20:120

    Content type: Research article

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  15. Age-related macular degeneration (AMD) represents the leading cause of visual impairment in the aging population. The goal of this study was to identify aberrantly-methylated, differentially-expressed genes (M...

    Authors: Yinchen Shen, Mo Li, Kun Liu, Xiaoyin Xu, Shaopin Zhu, Ning Wang, Wenke Guo, Qianqian Zhao, Ping Lu, Fudong Yu and Xun Xu

    Citation: BMC Ophthalmology 2020 20:119

    Content type: Research article

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  16. Peters plus syndrome (PPS) is a combination of congenital Peters anomaly and systemic abnormalities. It is inherited most commonly in an autosomal recessive pattern with homozygous B3GLCT mutations. Ocular findin...

    Authors: Ye Elaine Wang, Dhariana Acon Ramirez, Ta Chen Chang and Audina Berrocal

    Citation: BMC Ophthalmology 2020 20:118

    Content type: Case report

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  17. A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surge...

    Authors: Henry Bair, Chun-Ju Lin, Chun-Ting Lai, Ning-Yi Hsia and Yi-Yu Tsai

    Citation: BMC Ophthalmology 2020 20:117

    Content type: Case report

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  18. To evaluate the feasibility of a surgical technique using a sub-perfluoro-n-octane (PFO) injection of ocular viscoelastic device (OVD) to stabilize inverted internal limiting membrane (ILM) flap for the treatm...

    Authors: Chi-Chun Lai, An-Lun Wu, Hung-Da Chou, Wee Min Teh, Kuan-Jen Chen, Yen-Po Chen, Laura Liu, Yih-Shiou Hwang and Wei-Chi Wu

    Citation: BMC Ophthalmology 2020 20:116

    Content type: Research article

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  19. This study aimed to evaluate the visual and morphological outcomes of intravitreal anti-VEGF therapy and the recurrence for idiopathic choroidal neovascularization (ICNV).

    Authors: Qianru Wu, Xiaoyong Chen, Kang Feng, Yuling Liu, Chun Zhang and Lin Zhao

    Citation: BMC Ophthalmology 2020 20:115

    Content type: Research article

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  20. Classification of optical coherence tomography (OCT) images can be achieved with high accuracy using classical convolution neural networks (CNN), a commonly used deep learning network for computer-aided diagno...

    Authors: Takumasa Tsuji, Yuta Hirose, Kohei Fujimori, Takuya Hirose, Asuka Oyama, Yusuke Saikawa, Tatsuya Mimura, Kenshiro Shiraishi, Takenori Kobayashi, Atsushi Mizota and Jun’ichi Kotoku

    Citation: BMC Ophthalmology 2020 20:114

    Content type: Research article

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  21. Bilateral diffuse uveal melanocytic proliferation (BDUMP) is an extremely rare paraneoplastic syndrome, with most cases reported as secondary to female urogenital and male lung malignancies. We reported this c...

    Authors: Mingyue Luo, Zhe Chen, Yaping Luo, Lin Zhao, Rongping Dai and Yong Zhong

    Citation: BMC Ophthalmology 2020 20:113

    Content type: Case report

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  22. In this case presentation, we present a young vegan patient who developed a CRVO secondary to severe iron-deficiency anaemia (IDA) attributable to menstrual losses and limited iron intake. CRVO is a rare compl...

    Authors: Verlyn Yang, Liam Daniel Turner and Fraser Imrie

    Citation: BMC Ophthalmology 2020 20:112

    Content type: Case report

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  23. The aim of this study was to evaluate the efficacy and safety of M22 Optimal Pulsed Technology (OPT) applied in patients with age-related cataract and Meibomian gland dysfunction (MGD) in perioperative period.

    Authors: Jinling Ge, Na Liu, Xiaoming Wang, Ying Du, Chaoqing Wang, Zhaorui Li, Jing Li and Lihua Wang

    Citation: BMC Ophthalmology 2020 20:111

    Content type: Research article

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  24. To evaluate the differences between the predicted and achieved lenticule thickness (ΔLT) after small incision lenticule extraction (SMILE) surgery and investigate relationships between ΔLT and predicted lentic...

    Authors: Fang Wu, Houfa Yin, Xinyi Chen and Yabo Yang

    Citation: BMC Ophthalmology 2020 20:110

    Content type: Research article

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  25. Macular hole (MH) is a retinal break in the fovea involving partial or complete dehiscence of the neural retinal layers affecting the visual quality by decreasing visual acuity (VA) and visual deformation. We ...

    Authors: Minami Chino, Yuji Yoshikawa, Junji Kanno, Takamitsu Nagashima, Yu Sakaki, Takeshi Katsumoto, Masayuki Shibuya, Takuhei Shoji, Jun Makita and Kei Shinoda

    Citation: BMC Ophthalmology 2020 20:108

    Content type: Case report

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  26. To measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis.

    Authors: Yan Zhang, Jianqing Lan, Dan Cao, Cheng Yang, Dawei Yang, Wenjuan Xie and Jin Zeng

    Citation: BMC Ophthalmology 2020 20:107

    Content type: Research article

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  27. Blood-retinal barrier cells are known to exhibit a massive phenotypic change during experimental autoimmune uveitis (EAU) development. In an attempt to investigate the mechanisms of blood-retinal barrier (BRB)...

    Authors: Deborah A. Lipski, Vincent Foucart, Rémi Dewispelaere, Laure E. Caspers, Matthieu Defrance, Catherine Bruyns and François Willermain

    Citation: BMC Ophthalmology 2020 20:106

    Content type: Research article

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  28. To study the morphologic and biochemical changes in the retina and sclera induced by form deprivation high myopia (FDHM) in guinea pigs and explore the possible mechanisms of FDHM formation.

    Authors: Yingxin Zi, Yu Deng, Jingru Zhao, Meiqi Ji, Yali Qin, Tingting Deng and Ming Jin

    Citation: BMC Ophthalmology 2020 20:105

    Content type: Research article

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  29. The purpose was to describe the Nordic treatment practices and to reach a Nordic consensus for the treatment of sebaceous eyelid carcinoma.

    Authors: Tiina Leivo, Johanna Sarmela, Maria Enckell-Aaltonen, Eva Dafgård Kopp, Caroline Schmitt, Peter B. Toft, Haraldur Sigurdsson and Marita Uusitalo

    Citation: BMC Ophthalmology 2020 20:103

    Content type: Research article

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  30. In diabetic eyes, various choroidal abnormalities are noted in addition to changes in the retinal circulation, and the risk of increased aqueous flare and retinal thickening after cataract surgery is higher in...

    Authors: Yasuko Ikegami, Miyuki Takahashi and Kana Amino

    Citation: BMC Ophthalmology 2020 20:102

    Content type: Research article

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  31. Pseudoduplication of the optic disc is a rare clinical condition that is characterized by a circumscribed, disc-like lesion with radiating vessels but only one normal optic nerve. We report a rare case that in...

    Authors: Liuhui Huang, Qi Zhang, Haiying Jin and Peiquan Zhao

    Citation: BMC Ophthalmology 2020 20:101

    Content type: Case report

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  32. The aim of this study was to review the demographic and characteristic distribution data of serious rural pediatric eye injuries in Wenzhou and Changsha, located in Zhejiang Province in East China and Hunan Pr...

    Authors: Chunyan Li, Yaoyao Lin, Haishao Xiao, Huan Lin, Yanyan Chen and Minhui Dai

    Citation: BMC Ophthalmology 2020 20:100

    Content type: Research article

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  33. To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation.

    Authors: Ji-Sun Paik, Kyungdo Han, Suk-Woo Yang, Yongkyu Park, Kyungsun Na, Wonkyung Cho, Su-Kyung Jung and Sungeun Kim

    Citation: BMC Ophthalmology 2020 20:99

    Content type: Research article

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  34. Systemic lupus erythematosus (SLE) can directly affect various part of the ocular system, but there was no comprehensive analysis of ophthalmic disorders of patients with SLE using population-based data. The a...

    Authors: Chun-Shuo Hsu, Chia-Wen Hsu, Ming-Chi Lu and Malcolm Koo

    Citation: BMC Ophthalmology 2020 20:96

    Content type: Research article

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  35. This study aimed to investigate the pre- and post-surgery reading ability in patients with idiopathic epiretinal membrane (ERM) to evaluate whether measurement of reading performance is a helpful test in addit...

    Authors: Hiroki Mieno, Kentaro Kojima, Kazuhito Yoneda, Fumie Kinoshita, Rentaro Mizuno, Shinnosuke Nakaji and Chie Sotozono

    Citation: BMC Ophthalmology 2020 20:95

    Content type: Research article

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  36. Hematologic malignancies occasionally cause serous retinal detachment (SRD); however, its pathogenesis remains unclear. Here we present the imaging characteristics of metastatic choroidal lymphoma masquerading...

    Authors: Kanae Fukutsu, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Satoru Kase, Kayo Suzuki, Hiroshi Shimizu, Yukiko Shibata, Fumihiko Yamawaki, Masahiro Onozawa and Susumu Ishida

    Citation: BMC Ophthalmology 2020 20:94

    Content type: Case report

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  37. Retinoblastoma (RB) is the most frequent pediatric retinal tumor. In the present study, to elucidate chemoresistance mechanisms and identify potential biomarkers in RB, we utilized RNA sequencing (RNAseq) tech...

    Authors: Wen-ping Song, Si Zheng, Hong-juan Yao, Xiao-fei Zhou, Rui Li, Cheng-yue Zhang, Jun-yang Zhao, Lie-wei Wang, Rong-guang Shao and Liang Li

    Citation: BMC Ophthalmology 2020 20:92

    Content type: Research article

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  38. To compare vision-related quality of life (VRQOL) between acute and chronic Central serous chorioretinopathy (CSC) and correlate this with Cohen’s Perceived Stress Scale (PSS) questionnaire.

    Authors: Meenakshi Kumar, Elon H. C. van Dijk, Rajiv Raman, Pooja Mehta, Camiel J. F. Boon, Abhilash Goud, Seelam Bharani and Jay Chhablani

    Citation: BMC Ophthalmology 2020 20:90

    Content type: Research article

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  39. We aimed to demonstrate the contribution of anti-inflammatory and anti-virulence effects of azithromycin (AZM) in ocular surface infection treatment.

    Authors: Kana Ikemoto, Shinya Kobayashi, Yu Haranosono, Seiko Kozai, Tomoyuki Wada, Hideki Tokushige and Akio Kawamura

    Citation: BMC Ophthalmology 2020 20:89

    Content type: Research article

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