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  1. In response to the COVID-19 pandemic, a web-based tele-triage system was created to prioritize in-person clinic visits and ensure safety at the University of Illinois at Chicago Department of Ophthalmology and...

    Authors: Angelica C. Scanzera, Arthur Y. Chang, Nita Valikodath, Emily Cole, Joelle A. Hallak, Thasarat Sutabutr Vajaranant, Sage J. Kim and R. V. Paul Chan

    Citation: BMC Ophthalmology 2021 21:346

    Content type: Research

    Published on:

  2. The purpose of this study was to implement and evaluate a deep learning (DL) approach for automatically detecting shallow anterior chamber depth (ACD) from two-dimensional (2D) overview anterior segment photog...

    Authors: Zhuyun Qian, Xiaoling Xie, Jianlong Yang, Hongfei Ye, Zhilei Wang, Jili Chen, Hui Liu, Jianheng Liang, Lihong Jiang, Ce Zheng and Xu Chen

    Citation: BMC Ophthalmology 2021 21:341

    Content type: Research

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  3. Anterior segment surgeries such as cataract surgery, intraocular lens (IOL) repositioning, and radial keratotomy (RK) may hasten endothelial dysfunction, particularly in the context of pre-existing Fuchs dystr...

    Authors: Anvesh Annadanam, Timothy Soeken, Manjool Shah and Nambi Nallasamy

    Citation: BMC Ophthalmology 2021 21:340

    Content type: Case report

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  4. In vivo corneal biomechanics evaluation has been used to help screen early keratoconus in recent years. This study is to evaluate the value of a Scheimpflug-based biomechanical analyser combined with tomograph...

    Authors: Yan Liu, Yu Zhang and Yueguo Chen

    Citation: BMC Ophthalmology 2021 21:339

    Content type: Research article

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  5. Imaging mass cytometry (IMC) combines the principles of flow cytometry and mass spectrometry (MS) with laser scanning spatial resolution and offers unique advantages for the analysis of tissue samples in unpre...

    Authors: Anja Schlecht, Stefaniya Boneva, Henrike Salie, Saskia Killmer, Julian Wolf, Rozina Ida Hajdu, Claudia Auw-Haedrich, Hansjürgen Agostini, Thomas Reinhard, Günther Schlunck, Bertram Bengsch and Clemens AK Lange

    Citation: BMC Ophthalmology 2021 21:338

    Content type: Technical advance

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  6. Acute retinal necrosis is considered a rare infectious uveitis. This condition is usually caused by varicella-zoster virus or herpes simplex virus. Acute retinal necrosis caused by co-infection with multiple v...

    Authors: Kasra Cheraqpour, Aliasghar Ahmadraji, Ali Rashidinia, Maziyar Irannejad and Mansoor Shahriari

    Citation: BMC Ophthalmology 2021 21:337

    Content type: Case report

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  7. There are few reports regarding the influence of varying illumination on the compensation effect before and after corneal refractive surgery. We aimed to evaluate the changes in refraction, higher-order aberra...

    Authors: Weiting Hao, Yan Wang, Tong Cui, Wenxing Ning, Qing Zhu and Yaohua Zhang

    Citation: BMC Ophthalmology 2021 21:336

    Content type: Research

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  8. Leukemic involvement of the eyes is rare, therefore, treatment relies on previous case reports. The treatment of ocular complications poses additional difficulties, because the eye is considered as a pharmacol...

    Authors: Douglas Rodrigues da Costa, Rodrigo Dahia Fernandes, Fernanda Nicolela Susanna, Epitácio Dias da Silva Neto and Mario Luiz Ribeiro Monteiro

    Citation: BMC Ophthalmology 2021 21:335

    Content type: Case report

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  9. To evaluate the relevance of external limiting membrane (ELM) on the visual and morphological results in eyes with diabetic macular edema (DME) that underwent pars plana vitrectomy (PPV) with epiretinal membra...

    Authors: Ivastinovic Domagoj, Haas Anton, Weger Martin, Seidel Gerald, Mayer-Xanthaki Christoph, Lindner Ewald, Guttmann Andreas and Wedrich Andreas

    Citation: BMC Ophthalmology 2021 21:334

    Content type: Research article

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  10. Plasma medicine is an innovative research field focused on the application of atmospheric-pressure low-temperature plasmas (ALTP) for therapeutic purposes. Considering the potentials of plasma in ophthalmology...

    Authors: Farhad Nejat, Khosrow Jadidi, Fahimeh Asadi Amoli, Shiva Bagheri, Hossein Aghamollaei, Mohammad-Amin Nejat, Nazanin-Sadat Nabavi and Shima Eghtedari

    Citation: BMC Ophthalmology 2021 21:333

    Content type: Research

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  11. The present study sought to observe the effect of retaining intact posterior capsule in congenital cataract surgery in children aged 4–8 years.

    Authors: Jing Shang Zhang, Jin Da Wang, Mayinuer Yusufu, Kai Cao, Shan Shan Jin, Ying Xiong, Jing Li, Xiu Li Sun, Shu Ying Chen, Zhen Yu Liu, Jing Fu, Li Li, Qi Sheng You and Xiu Hua Wan

    Citation: BMC Ophthalmology 2021 21:332

    Content type: Research

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  12. To evaluate macular microstructure alterations in the parafoveal nonperfusion areas of eyes with branch retinal vein occlusions (BRVO), and to investigate their impact on retinal sensitivity.

    Authors: Puying Wei, Chenchen Liu, Yanzhen Zhang and Liu Yang

    Citation: BMC Ophthalmology 2021 21:331

    Content type: Research

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  13. To assess the effects of warm compress (WC) on tear film lipid layer, blink pattern and Meibomian gland function in patients with dry eye following femtosecond laser small incision lenticule extraction (SMILE)...

    Authors: Xueyi Zhou, Yang Shen, Jianmin Shang and Xingtao Zhou

    Citation: BMC Ophthalmology 2021 21:330

    Content type: Research

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  14. To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surg...

    Authors: Houfa Yin, Xinyi Chen, Xiaogang Hong, Jian Ma, Fang Wu, Ting Wan, Yiwen Sang, Qiuli Fu, Zhenwei Qin, Danni Lyu, Wei Wu, Jinfu Yin and Yabo Yang

    Citation: BMC Ophthalmology 2021 21:329

    Content type: Research

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  15. The purpose of this study was to investigate diagnostic ability of peripapillary vessel density of primary angle closure glaucoma (PACG) eyes in quadrant and clock-hour sectors by optical coherence tomography ...

    Authors: Yongdong Lin, Shirong Chen and Mingzhi Zhang

    Citation: BMC Ophthalmology 2021 21:328

    Content type: Research

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  16. Neurotrophic keratopathy (NK) is a relatively uncommon, underdiagnosed degenerative corneal disease that is caused by damage to the ophthalmic branch of the trigeminal nerve by conditions such as herpes simple...

    Authors: Reza Dana, Marjan Farid, Preeya K. Gupta, Pedram Hamrah, Paul Karpecki, Cathleen M. McCabe, Lisa Nijm, Jay S. Pepose, Stephen Pflugfelder, Christopher J. Rapuano, Arvind Saini, Sarah N. Gibbs and Michael S. Broder

    Citation: BMC Ophthalmology 2021 21:327

    Content type: Research

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  17. Highly myopic eyes differ in morphology from emmetropic eyes, and the correct estimation of the vitreous volume is difficult. To explore an effective method to estimate ocular volume using refractive factors i...

    Authors: Xiaodan Jiang, Hongwei Deng, Chun Lung, Fanyin Wang, Shuang Li, Yanni Jiang and Mingyue Wang

    Citation: BMC Ophthalmology 2021 21:326

    Content type: Research

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  18. Designing educational interventions tailored to the needs of Contact Lens Wearers (CLWs) are important and necessary. The present study aimed to determine the information needs of CLWs to educate and provide i...

    Authors: Fatemeh Falahati-Marvast, Fateme Alipour, Jamileh Farokhzadian and Leila Ahmadian

    Citation: BMC Ophthalmology 2021 21:325

    Content type: Research

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  19. The combined corticosteroid regimen of the original Optic Neuritis Treatment Trial (ONTT) is used in many centers to treat optic neuritis. Though pattern reversal visual evoked potentials (PRVEPs) are a sensit...

    Authors: Padmini Dahanayake, Tharaka L. Dassanayake, Manoji Pathirage, Saman Senanayake, Mike Sedgwick and Vajira S. Weerasinghe

    Citation: BMC Ophthalmology 2021 21:324

    Content type: Research

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  20. Ocular parasitosis can cause eye damage, which contribute to eye symptoms such as burning, itching and even blindness. It is uncommon to see the parasitosis lying in the sclera layer, neither it causing pteryg...

    Authors: Wenjie Zeng, Zhaoyi Pan, Jun Wang, Xianghui Deng and Wenmin Jiang

    Citation: BMC Ophthalmology 2021 21:323

    Content type: Case report

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  21. Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal...

    Authors: Chia-Ying Lee, Chung-May Yang, Chang-Hao Yang, Fung-Rong Hu and Ta-Ching Chen

    Citation: BMC Ophthalmology 2021 21:322

    Content type: Case report

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  22. Regular membrane peeling vitrectomy for epiretinal membrane (ERM) patients seldom causes large pigment epithelial detachment (PED). We presented an unusual case of the activation of quiescent polypoidal choroi...

    Authors: Yuelin Wang, Zhe Chen, Weihong Yu and Youxin Chen

    Citation: BMC Ophthalmology 2021 21:321

    Content type: Case report

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  23. We report a case of bilateral pachychoroid disease manifesting polypoidal choroidal vasculopathy (PCV) with punctate hyperfluorescent spot (PHS) in one eye, and peripheral exudative hemorrhagic choroidal retin...

    Authors: Yorihisa Kitagawa, Hiroyuki Shimada, Akiyuki Kawamura, Koji Tanaka, Ryusaburo Mori, Hajime Onoe and Hiroyuki Nakashizuka

    Citation: BMC Ophthalmology 2021 21:320

    Content type: Case report

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  24. Long-term use of topical, especially benzalkonium chloride (BAC)-preserved, antiglaucoma medications can cause a negative impact on the ocular surface. The aim of the study was to assess the effect of topical ...

    Authors: Lech Sedlak, Marta Świerczyńska, Weronika Borymska, Maria Zych and Dorota Wyględowska-Promieńska

    Citation: BMC Ophthalmology 2021 21:319

    Content type: Research

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  25. Tick-borne encephalitis (TBE) is an infectious disease of the central nervous system caused by the TBE virus (TBEV), which is usually transmitted by a tick-bite, with increasing incidence in northeastern Europ...

    Authors: Nafsika Voulgari, Claire-May Blanc, Vanessa Guido, Daniele C. Rossi, Yan Guex-Crosier and Florence Hoogewoud

    Citation: BMC Ophthalmology 2021 21:315

    Content type: Case report

    Published on:

  26. Ectopic thyroid tissue in the iris, also known as a thyroid glandular epithelial choristoma of the iris, has only been described twice in the literature. In both cases it remained asymptomatic.

    Authors: Helena Wagner, Claudia Auw-Hädrich, Martin Werner and Thomas Reinhard

    Citation: BMC Ophthalmology 2021 21:314

    Content type: Case report

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  27. Blepharochalasis is a rare eyelid disorder but eventually leading to destructive eyelid deformation. Until now the clinical and epidemiological data are unavailable. This study aimed to report the manifestatio...

    Authors: Jinqiong Zhou, Jingwen Ding and Dongmei Li

    Citation: BMC Ophthalmology 2021 21:313

    Content type: Research article

    Published on:

  28. To evaluate the incidence of sustained elevation of intraocular pressure (SE-IOP) associated with intravitreal injections of anti-vascular endothelial growth factors (anti-VEGF) bevacizumab and aflibercept in ...

    Authors: Mikael Kähkönen, Raimo Tuuminen and Vesa Aaltonen

    Citation: BMC Ophthalmology 2021 21:312

    Content type: Research

    Published on:

  29. Myopic anisometropic amblyopia in pediatrics is one of the most challenging clinical situations that can face an ophthalmologist. Conventional correction modalities for myopic anisometropia, using spectacles, ...

    Authors: Fathy Fawzy Morkos, Nader F. Fawzy, Mohamed El Bahrawy, Nada Fathy and Rania Serag Elkitkat

    Citation: BMC Ophthalmology 2021 21:311

    Content type: Research

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  30. This study aimed to develop a Thai version of the Dry Eye–Related Quality-of-Life Score (DEQS-Th) questionnaire and evaluate its validity, reliability, and feasibility among Thai participants.

    Authors: Sasiwimon Tansanguan, Napaporn Tananuvat, Nahathai Wongpakaran, Tinakon Wongpakaran and Somsanguan Ausayakhun

    Citation: BMC Ophthalmology 2021 21:310

    Content type: Research

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  31. To analyze blood flow volume alteration that involved both retrobulbar artery and internal carotid artery (ICA) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) and to assess their rel...

    Authors: Zhiyong Fu, Hongyang Li and Yanling Wang

    Citation: BMC Ophthalmology 2021 21:309

    Content type: Research

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  32. This article is a case report of pseudoxanthoma elasticum (PXE) which was diagnosed based on significant angioid streaks (AS) with choroidal neovascularization (CNV) and regain normal visual function by intrav...

    Authors: Chaoxiong Cui, Zhanyu Zhou, Yi Zhang and Ding Sun

    Citation: BMC Ophthalmology 2021 21:307

    Content type: Case report

    Published on:

  33. Our aim was to determine associations of pachymetry, keratometry, and their changes with haze formation and corneal flattening after collagen cross-linking, and to analyse the relationship between postoperativ...

    Authors: Anita Csorba, Kinga Kránitz, Péter Dormán, Andrea Popper-Sachetti, Huba Kiss, Irén Szalai and Zoltán Zsolt Nagy

    Citation: BMC Ophthalmology 2021 21:306

    Content type: Research article

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  34. The nasal to temporal amplitudes ratio (N/T) of multifocal electroretinography (mfERG) scans measured within 5° of the macula can be used to detect glaucomatous change. The photopic negative response (PhNR) of...

    Authors: Hiroki Tanaka, Kyoko Ishida, Kenji Ozawa, Takuma Ishihara, Akira Sawada, Kiyofumi Mochizuki and Tetsuya Yamamoto

    Citation: BMC Ophthalmology 2021 21:305

    Content type: Research article

    Published on:

  35. The efficacies of prism adaptation test (PAT) and monocular occlusion (MO) and their optimal test durations to detect the maximum angles of deviation at near and distance in eyes with intermittent exotropia (I...

    Authors: Ryota Takada, Fumiko Matsumoto, Akemi Wakayama, Takuya Numata, Fumi Tanabe, Kosuke Abe and Shunji Kusaka

    Citation: BMC Ophthalmology 2021 21:304

    Content type: Research article

    Published on:

  36. The influences of intraocular pressure (IOP) elevations on the pulse waveform in the optic nerve head (ONH) were evaluated using laser speckle flowgraphy (LSFG) in normal subjects.

    Authors: Chie Iwase, Takeshi Iwase, Ryo Tomita, Tomohiko Akahori, Kentaro Yamamoto, Eimei Ra and Hiroko Terasaki

    Citation: BMC Ophthalmology 2021 21:303

    Content type: Research

    Published on:

  37. Retinitis pigmentosa (RP) is a rare, progressive, and hereditary disorder that leads to the progressive loss of vision and visual field, and in some cases blindness. The specific relationship between RP and gl...

    Authors: Wei-ning Li, Xiu-juan Du, Yu-ting Zhang, Le-yi Wang and Jing Zhu

    Citation: BMC Ophthalmology 2021 21:302

    Content type: Research

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  38. During the first wave of the COVID-19 pandemic, the need of treatment of urgent ophthalmological diseases and the possible risk of a SARS-CoV-2 infection had to be weighed against each other. In this questionn...

    Authors: Christoph Ehlken, Constantin von Medem, Maya Lüdemann, Anna Maria Kirsch and Johann Baptist Roider

    Citation: BMC Ophthalmology 2021 21:301

    Content type: Research article

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  39. To describe real-life data from wet age-related macular degeneration (AMD) patients treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical t...

    Authors: Paolo Corazza, Francesco Maria D’Alterio, Jamil Kabbani, Mostafa Mohamed Ragheb Alam, Stefano Mercuri, Harry Otway Orlans and Saad Younis

    Citation: BMC Ophthalmology 2021 21:300

    Content type: Research

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  40. To evaluate the prevalence of myopia in school students in Urumqi, China, and explore the influence of the interaction between parental myopia and poor reading and writing habits on myopia to identify the at-r...

    Authors: Haonan Shi, Jing Fu, Xiaojing Liu, Yingxia Wang, Xianting Yong, Lan Jiang, Shaowei Ma, Zhe Yin, Jian Yao, Xuan Yao, Xueyi Chen and Tingting Wang

    Citation: BMC Ophthalmology 2021 21:299

    Content type: Research article

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  41. To compare the efficacies in astigmatic correction of simultaneous femtosecond laser-assisted cataract surgery (FLACS) with intrastromal arcuate keratotomy (ISAK) versus toric intraocular lens (IOL) implantati...

    Authors: Hye Ji Kwon, Hun Lee, Jin Ah. Lee, Jae Yong Kim and Hungwon Tchah

    Citation: BMC Ophthalmology 2021 21:298

    Content type: Research article

    Published on:

  42. EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle clo...

    Authors: Jing Wang, Ming-shui Fu, Min-wen Zhou, Bi-lian Ke, Zhi-hua Zhang and Xun Xu

    Citation: BMC Ophthalmology 2021 21:297

    Content type: Research article

    Published on:

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