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Table 6 Comparison of baseline characteristics and clinical efficacy between site No.7 versus other sites.

From: Newly diagnosed exudative age-related macular degeneration treated with pegaptanib sodium monotherapy in US community-based practices: medical chart review study

Characteristic Site No.7 Other sites p-value
Baseline best-corrected VA (logMAR)    
   Mean (SD) 0.61 (0.26) 0.62 (0.24) 0.8429
Time from NV-AMD diagnosis to baseline (months)    
   N 18 55  
   Mean (SD) 0.33 (0.77) 3.13 (6.65) 0.0808
   Median (range) 0.0 (0--3) 0.0 (0--31)  
Angiographic subtype, n (%)    0.1937
   Minimally classic 0 (0.0) 4 (7.3)  
   Occult 12 (66.7) 43 (78.2)  
   Predominantly classic 5 (27.8) 6 (10.9)  
   Missing 1 (5.6) 2 (3.6)  
Lesion size (disc area), n (%)    0.1376
   <2 9 (50.0) 17 (30.9)  
   ≥ 2 and < 4 7 (38.9) 15 (27.3)  
   ≥ 4 1 (5.6) 10 (18.2)  
   Missing 1 (5.6) 13 (23.6)  
Geographic atrophy, n (%)    0.0545
   Present 0 (0.0) 10 (18.2)  
   Absent 17 (94.4) 37 (67.3)  
   Missing 1 (5.6) 8 (14.5)  
Presence of blood, n (%)    0.4277
   Present 4 (22.2) 21 (38.2)  
   Absent 13 (72.2) 30 (54.5)  
   Missing 1 (5.6) 4 (7.3)  
Met early disease definition No.1* 5 (29.4) 13 (31.0) 1.0000
Met early disease definition No.2 5 (29.4) 30 (61.2) 0.0281
VA, baseline to month 6 (logMAR)
Mean (SD)
-0.04 (0.22) 0.11 (0.36) 0.0970
VA change, baseline to month 6    
   Gained ≥ 0 lines 15 (83.3) 27 (49.1) 0.0134
   Gained ≥ 3 lines 3 (16.7) 9 (16.4) 1.0000
   Lost < 3 lines 1 (5.6) 8 (14.5) 0.4365
   Lost ≥ 6 lines 0 (0.0) 8 (14.5) 0.1871
  1. * Early disease definition No.1: lesion size <2 disk area, baseline VA study eye ≥ 20/80 Snellen, no scar or atrophy.
  2. Early disease definition No.2: occult and better VA at baseline in fellow eye (worse in study eye).
  3. LogMAR = logarithm of the minimum angle of resolution; NV-AMD = neovascular age-related macular degeneration; SD = standard deviation; VA = visual acuity.