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Table 3 Microbial reduction (log10 CFU/mL) by time point

From: Effectiveness of ophthalmic solution preservatives: a comparison of latanoprost with 0.02% benzalkonium chloride and travoprost with the sofZia preservative system

Sample Microorganism Inoculum 0 hours 6 hours 24 hours 7 days 14 days 28 days
Latanoprost 0.005% (Lot No: LA54019) S. aureus 5.8 > 4.8 > 4.8 > 4.8 > 4.8 > 4.8 > 4.8
  P. aeruginosa 5.7 4.7 > 4.7 > 4.7 > 4.7 > 4.7 > 4.7
  E. coli 6.0 > 5.0 > 5.0 > 5.0 > 5.0 > 5.0 > 5.0
  C. albicans 5.7 0.9 > 4.7 > 4.7 > 4.7 > 4.7 > 4.7
  A. brasiliensis 5.4 0.1 > 4.4 > 4.7 > 4.4 > 4.4 > 4.4
Travoprost 0.004% (Lot No: 158568F) S. aureus 5.8 0 0.1 0.2 > 4.8 > 4.8 > 4.8
  P. aeruginosa 5.7 0.1 0.8 1.7 > 4.7 > 4.7 > 4.7
  E. coli 6.0 0.3 1.5 2.8 > 5.0 > 5.0 > 5.0
  C. albicans 5.7 0.1 0.2 0.1 0.6 1.0 1.8
  A. brasiliensis 5.4 0.1 0.2 0.9 1.7 1.9 1.8
  1. CFU: colony-forming unit.
  2. Latanoprost ophthalmic solution 0.005% contains 0.02% benzalkonium chloride and travoprost ophthalmic solution 0.004% contains sofZia as preservatives.
  3. Shading indicates results not meeting European Pharmacopoeia-A (EP-A) requirements [11] (note that while testing of E. coli is required only for non-oral products in the EP, this would be considered a failing result).