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Table 3 The total score for the eye is the sum of all scores obtained for the cornea, iris, and conjunctivae, with the possible maximum total score for the eye being equal to 110

From: Ocular toxicity of authentic lunar dust

I. Cornea (Maximum score = 80; A x B x 5)

A. Opacity‐degree (area most dense taken for reading)

No opacity

0

Slight dulling of normal luster

+

Scattered or diffuse areas of opacity (other than slight dulling of normal luster), details of iris clearly visible

1

Easily discernible translucent area, details of iris slightly obscured

2

Nacreous area, no details of iris visible, size of pupil barely discernible

3

Opaque cornea, iris not discernible through the opacity

4

B. Area of cornea involved

One quarter (or less), but not zero

1

Greater than one quarter, but less than half

2

Greater than half, but less than three quarters

3

Greater than three quarters, up to whole area

4

C. Fluorescein staining‐appearance of yellow-green staining of cornea

Cornea not examined with fluorescein

-

No fluorescein staining

0

Positive fluorescein staining

P

Area of cornea involved

 

One quarter (or less), but not zero

A

Greater than one quarter, but less than half

B

Greater than half, but less than three quarters

C

Greater than three quarters, up to whole area

D

D. Stippling‐appearance of pinpoint roughening

No stippling

0

Presence of stippling

S

Area of cornea involved

 

One quarter (or less), but not zero

A

Greater than one quarter, but less than half

B

Greater than half, but less than three quarters

C

Greater than three quarters, up to whole area

D

II. Iris (Maximum score = 10; A x 5)

A. Grades

Normal

0

Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperemia or injection (any of these or combination thereof), iris still reacting to light (sluggish reaction is positive)

1

No reaction to light, hemorrhage, gross destruction (any or all of these)

2

III. Conjunctivae (Maximum score = 20; (A+B+C) x 2)

A. Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris)

Blood vessels normal

0

Some blood vessels definitely hyperemic (injected)

1

Diffuse, crimson color, individual vessels not easily discernible

2

Diffuse beefy red

3

B. Chemosis: lids and/or nictitating membrane

No swelling

0

Any swelling above normal (includes nictitating membrane)

1

Obvious swelling with partial eversion of lids

2

Swelling with lids about half closed

3

Swelling with lids more than half closed

4

C. Discharge

No discharge

0

Any amount different from normal (does not include small amounts observed in inner canthus of normal animals)

1

Discharge with moistening of the lids and hairs just adjacent to lids

2

Discharge with moistening of the lids and hairs, and considerable area around the eye

3

D. Necrosis or ulceration of the palpebral and bulbar conjunctivae or nictitating membrane

No necrosis or ulceration

0

Presence of necrosis or ulceration

N