Figure 11
From: Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice
Inhibition of ischemia-induced retinal neovascularization by UNC5B shRNA. (a, c) Retinas transfected with scrambled shRNA. (b, d) Retinas transfected with UNC5B shRNA. (e) Quantification of retinal neovascularization. (a, b) Angiographic analysis by fluorescein-dextran, the numbers of neovascular tufts (marked by white arrows) are reduced in the retinas transfected with UNC5B shRNA. (c,d) Histological demonstration of retinal neovascularization, UNC5B shRNA infection results in approximately a 50% reduction of preretinal neovascularization. GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer. Bar = 50 μm.