Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy

Table 5 Genotype and allele distributions in PCV patients and control group

			Total PCV patients			Polypoidal CNV			Typical PCV			Control
			Number	%	p-value	Number	%	p-value	Number	%	p-value	Number	%
rs547154	Genotype	G/G	255	90.4%	80	95%	175	88%	229	84%
		T/G	26	9.2%	0.0400	4	5%	0.023	22	11%	0.276	41	15%
		T/T	1	0.4%		0	0%		1	1%		4	1%
	Dominant model	G/G	255	90.4%	0.016	80	95%	0.007*	175	88%	0.142	229	84%
		TG + TT	27	9.6%		4	5%		23	12%		45	16%
	Recessive model	TT	1	0.4%	0.168	0	0%	0.265	1	1%	0.317	4	1%
		TG + GG	281	99.6%		84	100%		197	99%		270	99%
	Allele	G	536	95.0%	0.009*	164	98%	0.004*	372	94%	0.110	499	91%
		T	28	5.0%		4	2%		24	6%		49	9%
rs541862	Genotype	T/T	255	90.4%		80	95%		175	88%		229	84%
		T/C	26	9.2%	0.049	4	5%	0.023	22	11%	0.318	42	15%
		C/C	1	0.4%		0	0%		1	1%		3	1%
	Dominant model	T/T	255	90.4%	0.016	80	95%	0.007*	175	88%	0.142	229	84%
		TC + CC	27	9.6%		4	5%		23	12%		45	16%
	Recessive model	C/C	1	0.4%	0.302	0	0%	0.336	1	1%	0.490	3	1%
		TC + TT	281	99.6%		84	100%		197	99%		271	99%
	Allele	T	536	95.0%	0.013	164	98%	0.004*	372	94%	0.137	500	91%
		C	28	5.0%		4	2%		24	6%		48	9%
rs2072633	Genotype	G/G	50	17.7%		13	15%		37	19%		69	25%
		G/A	131	46.5%	0.017	34	40%	0.005*	97	49%	0.149	134	49%
		A/A	101	35.8%		37	44%		64	32%		71	26%
	Dominant model	G/G	50	17.7%	0.032	13	15%	0.064	37	19%	0.095	69	25%
		GA + AA	232	82.3%		71	85%		161	81%		205	75%
	Recessive model	A/A	101	35.8%	0.012*	37	44%	0.002*	64	32%	0.128	71	26%
		GA + GG	181	64.2%		47	56%		134	68%		203	74%
	Allele	G	231	41.0%	0.004*	60	36%	0.002*	171	43%	0.055	272	50%
		A	333	59.0%		108	64%		225	57%		276	50%
rs4151667	Genotype	T/T	273	96.8%		81	96%		192	97%		261	95%
		A/T	9	3.2%	0.348	3	4%	0.649	6	3%	0.350	13	5%
		A/A	0	0.0%		0	0%		0	0%		0	0%
	Dominant model	T/T	273	96.8%	0.348	81	96%	0.649	192	97%	0.350	261	95%
		AT + AA	9	3.2%		3	4%		6	3%		13	5%
	Recessive model	A/A	0	0.0%	-	0	0%	-	0	0%	-	0	0%
		AT + TT	282	100.0%		84	100%		198	100%		274	100%
	Allele	T	555	98.4%	0.394	165	98%	0.775	390	98%	0.482	535	98%
		A	9	1.6%		3	2%		6	2%		13	2%

PCV; polypoidal choroidal vasculopathy CNV; choroidal neovascularization.
p- values are for the comparison between cases and controls.
p- values for genotypes were calculated by Fisher’s exact test. (after Bonferroni correction *p < 0.0125).

ISSN: 1471-2415