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Figure 2 | BMC Ophthalmology

Figure 2

From: A selective cyclic integrin antagonist blocks the integrin receptors αvβ3 and αvβ5and inhibits retinal pigment epithelium cell attachment, migration and invasion

Figure 2

A. RPE attachment on fibronectin, laminin and collagen IV. The cells were pretreated before the assay with the cyclic integrin antagonist, or the control peptide (10 μg/ml). Untreated RPE cells were used in addition as a standard (ST). B. RPE cell migration induced by PDGF-BB, VEGF and fibronectin. The effect of the cyclic integrin antagonist or the control peptide (cp) on migration is shown. (ST = untreated RPE cells) C. Effect of the cyclic integrin antagonist, (3 ug/ml) or the control peptide on RPE invasion through fibronectin. Cell invasion through fibronectin (F) was stimulated with PDGF-BB (10 ng/ml). Nonspecific effects were excluded by the use of a cyclic control peptide. DMEM without PDGF-BB was used as a control in the assay.

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BMC Ophthalmology

ISSN: 1471-2415

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