αA-crystallin R49Cneomutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice

Table 1 Phenotypic changes in wild type (WT), WT/R49C^neo heterozygous, and R49C^neo/R49C^neo homozygous mice.

A. Slit lamp analysis*
Genotype	Phenotype	Age Group			Total
	Nuclear and posterior changes by slit lamp biomicroscopy	<2 month	2–3 months	>4 months
WT		0/4	0/4	2/9	2/17 (0.12)
WT/R49C^neo		3/6	14/22	7/7	24/35 (0.68)
R49C^neo/R49C^neo		4/5	5/7	13/14	22/26 (0.85)
B. Histological analysis*
Genotype	Phenotype	Age Group			Total
	Swollen cells and/or posterior changes by histology	<1 month	2–3 months	>4 months
WT		0/5	1/4	1/7	2/16 (0.13)
WT/R49C^neo		4/11	2/4	2/3	8/18 (0.44)
R49C^neo/R49C^neo		4/5	3/4	6/8	13/17 (0.76)

* For each age group, the total number of mice analyzed is shown in the denominator, and the number of mice demonstrating the phenotype is shown in the numerator. The final columns show the total number of mice of each genotype that demonstrate a phenotype, with the proportion given in parentheses.

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