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Table 1 Phenotypic changes in wild type (WT), WT/R49Cneo heterozygous, and R49Cneo/R49Cneo homozygous mice.

From: αA-crystallin R49Cneomutation influences the architecture of lens fiber cell membranes and causes posterior and nuclear cataracts in mice

A. Slit lamp analysis*
Genotype Phenotype Age Group Total
  Nuclear and posterior changes by slit lamp biomicroscopy <2 month 2–3 months >4 months  
WT   0/4 0/4 2/9 2/17 (0.12)
WT/R49Cneo   3/6 14/22 7/7 24/35 (0.68)
R49Cneo/R49Cneo   4/5 5/7 13/14 22/26 (0.85)
B. Histological analysis*
Genotype Phenotype Age Group Total
  Swollen cells and/or posterior changes by histology <1 month 2–3 months >4 months  
WT   0/5 1/4 1/7 2/16 (0.13)
WT/R49Cneo   4/11 2/4 2/3 8/18 (0.44)
R49Cneo/R49Cneo   4/5 3/4 6/8 13/17 (0.76)
  1. * For each age group, the total number of mice analyzed is shown in the denominator, and the number of mice demonstrating the phenotype is shown in the numerator. The final columns show the total number of mice of each genotype that demonstrate a phenotype, with the proportion given in parentheses.