Table 4 Summary of meta-analysis results on healing of herpetic keratitis at day 7 for acyclovir versus idoxuridine with CMH method
Group | # of Articles included | Total number of Subjects | CMH Test for comparing ACV over IDU | BDT test for homogeneity of odds ratio | ||
|---|---|---|---|---|---|---|
ACV | IDU | CMH Statistics, P value | Common Odds Ratio 95% CI | χ 2 statistics (d.f.*), p value | ||
Herpetic keratitis | 7 | 214 | 218 | 44.54, < 0.0001 | 3.95 (2.60, 6.00) | 17.65 (6), 0.0072 |
Dendritic ulcers | 4 | 94 | 91 | 21.04, < 0.0001 | 4.22 (2.14, 8.32) | 20.71 (3), 0.0001 |
Geographic ulcers | 3 | 13 | 22 | 5.06, 0.0244 | 5.31 (1.09, 25.93) | 4.00 (2), 0.1350 |
Sensitivity Analysis (without data from [22]) | ||||||
Herpetic keratitis | 6 | 184 | 189 | 22.82, < 0.0001 | 2.96 (1.89, 4.66) | 2.69 (5), 0.7481 |
Dendritic ulcers | 3 | 64 | 62 | 1.24, 0.2657 | 1.62 (0.69, 3.81) | 3.10 (2), 0.2127 |