Histologic features of EMZL. (A) Low power magnification showing extensive infiltration of uvea, including choroid, iris, ciliary body and trabecular meshwork (HE; magnification × 20). (B) Higher power magnification demonstrating choroidal infiltration by tumor cells, with involvement of optic nerve and orbit (HE; magnification × 40). (C) Increased magnification illustrating the infiltrate of tumor cells with heavily pigmented lymphocytes in choroid and extension of malignant cells to retrobulbar tissue through sclera emissary canal (HE; magnification × 40). (D) High power magnification revealing an infiltrate of atypical lymphocytes with small irregular nuclei (HE; magnification × 400).