Ocular transient receptor potential channel function in health and disease

BMC Ophthalmology

Table 1 Characterization of TRP channel tissue localization

Name	Selectivity P_Ca:P_Na [12]	Activation threshold temperature (°C) [30]	Pharmacology [5, 42, 143]	Function [5, 30]	Posterior eye section	Anterior eye section
TRPC1	Non-selective	---	Store depletion, 2-APB	Component of SOC	Mouse retina [47, 48]	HCEC [60], TM [121]
TRPC2	2.7	---	DAG	?	Mouse retina [47, 48]	TM [121]
TRPC3	1.6	---	Store depletion, OAG, 2-APB, DAG, Pyr3	Component of SOC	Mouse retina [47, 48]	HCEC [60], TM [121]
TRPC4	1.1–9.0	---	Store depletion 2-APB	Component of SOC	Mouse retina [47, 48]	HCEC [60]
TRPV1	4–10	>43	Capsaicin, capsazepine, anandamide, NADA	Heat sensor osmosensor^a	Rat retina [49], human retina (tumor) [57], uvea (tumor) [59], human RPE [58, 59]	HCEC [63, 64], HCK [78], HCEC-12 [88]
TRPV2	1–3	>52	Cannabidiol, 2-APB	Heat sensor	Human RPE [58]	HCEC-12 [88]
TRPV3	2,6	30–39	Camphor, 2-APB	Moderate heat sensor	Human RPE [58]	HCEC [144], HCEC-12 [88]
TRPV4	6–10	24–27	4α-PDD, GSK 1016790A	Moderate heat sensor osmosensor^b	Mouse RGC [48], human RPE [58]	HCEC [75], HCEC-12 [87], HLE [94]
TRPM1	Not determed	---	mGluR6	Transduction of light signals	Mouse retina [47, 48, 145], human retina [51]	---
TRPM2	0.5–1.6		H₂O₂, ADP-ribose, β-NAD⁺	Mechanotransduction	---	HCEC-12 [28], TM [121]
TRPM7	3	---	Spermine		Mouse retina [47, 48], human retina [139]	---
TRPM8	1–3.3	<23–28	Menthol, icilin, eucalyptol, BCTC	Moderate cold sensor	Human retina (tumor) [57], uvea (tumor) [59]	HCEC^cHCNF [81], HCK^c, HCEC-12 [28, 89]
TRPA1	0,8	<17	Icilin, alicin	Cold sensor	Human retina (tumor) [57], uvea [59]	HCEC-12 [28, 89], TM [121]

ISSN: 1471-2415