Fig. 5
From: CD147 and matrix-metalloproteinase-2 expression in metastatic and non-metastatic uveal melanomas
Immunofluorescence microphotography (100x magnification field of view) of the retina (a) revealed an MMP-2 upregulation in all retinal layers with a lower density in the outer plexiform layer. CD147 was especially upregulated in the outer and inner nuclear layer. The epithelium of the ciliary body (b) revealed a moderate MMP-2 expression especially at the cell surface while CD147 was expressed in a low manner. The negative controls were performed by omitting the polyclonal primary CD147 and MMP-2 antibodies. Corneal epithelium revealed CD147 positivity in contrast to the stroma of the cornea (c). Scale bars: 100 μm