Fig. 3

In vivo confocal microscopy photography of the dystrophic corneas from IV:6 (a, b, c and d),III:10 (e, f, g and h), and normal confocal images from healthy relative (III:9, i, j, k and l). Depths from the corneal surface are given. Panel (a, e and i) show appearances of epithelial basal cell layer and Bowman’s layer (depth 20-40 μm). Panel (b, f and j) demonstrate findings of anterior corneal stroma layer close to Bowman’s layer (depth 40-60 μm). Panel (c, g and k) display images of mid-stroma layer (depth 220 μm). Panel (d, h and l) show the pictures of deep stroma layer close to DM and endothelium (depth 500 μm). Black arrows point hyper-reflective granular aggregates. White asterisks indicate the epithelial basal cell layer. White arrows point sub-basal nerve plexus. Spindle-shaped material and stromal nerve pointed by white triangle, and keratocyte nuclei pointed by white arrowheads