Fig. 3

Allelic variation of the rs7278468 alters the transcription of CRYAA. a The luciferase activity of CRYAA 5’UTR within either the T-C-G or C-G-T haplotype after being transfected into HLE cells. b Site–directed mutagenesis was applied to discern the impact of rs3761381, rs13053109 and rs7278468. The allele rs7278468 is mainly accounted for the transcriptional activity alteration of the CRYAA 5’UTR. The CRYAA 5’UTR with T-C-G were set to 1, to which other values were normalized. The results are shown as the mean ± SD. (*p < 0.05)