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Fig. 1 | BMC Ophthalmology

Fig. 1

From: Blue-light filtering alters angiogenic signaling in human retinal pigmented epithelial cells culture model

Fig. 1

Experiment 1: Light exposure under normoxia - Secretion of angiogenin, bFGF, and VEGF by RPE cells in the dark, or under white-light exposure, with or without a blue light filter. A significant (p < 0.05) decrease in angiogenin secretion was observed under white-light exposure when compared to dark conditions and a significant (p < 0.05) increase in bFGF secretion was observed under white light exposure when compared to dark conditions. However, although VEGF secretion was increased under white light exposure, this increase was not found to be statistically significant. Analyses were conducted using Welch’s unpaired t test. When assessing the effect of a blue light filter on the secretion of angiogenic factors following white light exposure, a significant (p < 0.05) increase was observed in angiogenin secretion levels. Although bFGF and VEGF levels were decreased in the presence of a blue light filter, this decrease was not statistically significant. (NS: non significant; * = P ≤ 0.05; ** ≤0.01)

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BMC Ophthalmology

ISSN: 1471-2415

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