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Table 1 Time-dependent changes in the tear inflammatory mediators after implantation

From: Comparison of femtosecond laser-assisted corneal intrastromal xenotransplantation and the allotransplantation in rhesus monkeys

 

1w

1 m

P-value

3 m

P-value

 

△IL-1β

Allotransplantation

0.112 Â± 0.008

0.111 Â± 0.016

0.999

0.700 Â± 1.212

0.343

Human to Monkey

47.367 Â± 6.208

2.867 Â± 0.252*

< 0.001

2.700 Â± 0.721*

< 0.001

Rabbit to Monkey

23.548 Â± 17.142

6.043 Â± 2.042*

0.048

2.836 Â± 1.806*

0.013

 

â–³IL-17

Allotransplantation

2.375 Â± 4.750

8.133 Â± 4.087

0. 694

48.467 Â± 56.687*

0.036

Human to Monkey

2.552 Â± 2.095

0.445 Â± 0.516

0.198

20.725 Â± 0.106*

< 0.001

Rabbit to Monkey

255.292 Â± 118.429

13.352 Â± 8.128*

< 0.001

2.773 Â± 3.084*

< 0.001

 

â–³IL-6

Allotransplantation

14.568 Â± 3.698

20.096 Â± 13.735

0.343

2.167 Â± 0.764*

0.040

Human to Monkey

15.856 Â± 3.782

0.793 Â± 0.777*

0.002

2.534 Â± 5.067*

0.003

Rabbit to Monkey

176.301 Â± 165.750

39.126 Â± 29.103*

0.010

8.909 Â± 7.047*

0.006

 

△TGF-β1

Allotransplantation

467.560 Â± 119.913

367.343 Â± 232.792

0.960

176.276 Â± 51.402

0.384

Human to Monkey

430.024 Â± 32.929

134.808 Â± 90.996*

0.009

189.715 Â± 86.430*

0.032

Rabbit to Monkey

2853.445 Â± 817.661

156.937 Â± 36.585*

< 0.001

49.067 Â± 8.359*

< 0.001

 

△TNF-α

Allotransplantation

−12.052 Â± 72.799

122.030 Â± 65.884*

0.011

−52.343 Â± 6.073

0.372

Human to Monkey

−65.852 Â± 23.792

52.223 Â± 15.819*

<0.001

−27.287 Â± 3.484*

0.025

Rabbit to Monkey

−17.137 Â± 3.357

−72.716 Â± 11.581*

0.015

−90.597 Â± 25.805*

0.002

 

△IFN-α

Allotransplantation

−16.527 Â± 14.725

0.820 Â± 0.743

0.062

−7.163 Â± 6.423

0.263

Human to Monkey

−90.817 Â± 5.225

−143.983 Â± 4.345*

< 0.001

−142.398 Â± 4.541*

< 0.001

Rabbit to Monkey

−117.396 Â± 58.082

−248.080 Â± 62.567*

0.035

−250.073 Â± 82.095*

0.023

  1. Statistically significant differences are compared with the 1 week postoperatively and indicated by *P < 0.05