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Table 2 Stratified analyses between the IL-1 gene polymorphisms and risk of POAG

From: Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis

Subgroup

No. of studies

No. of patients

Allele model

Homozygote model

Heterozygote model

Dominant model

Recessive model

Power calculationaz

Cases

Controls

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

IL-1β rs16944

Overall

5

1053

986

1.00 [0.78, 1.28]

1.00

1.03 [0.60, 1.76]

0.91

0.97 [0.79, 1.20]

0.77

0.97 [0.71, 1.31]

0.83

1.07 [0.71, 1.61]

0.74

5.1%

Asian

4

798

730

0.88 [0.76, 1.02]

0.09

0.79 [0.58, 1.06]

0.11

0.84 [0.65, 1.08]

0.18

0.82 [0.64, 1.05]

0.11

0.87 [0.69, 1.10]

0.26

42.2%

HTG

2

216

380

0.86 [0.67, 1.10]

0.24

0.76 [0.46, 1.27]

0.30

0.79 [0.51, 1.22]

0.28

0.78 [0.51, 1.18]

0.23

0.86 [0.58, 1.27]

0.45

23.8%

non-HTG

3

524

625

0.96 [0.75, 1.23]

0.73

0.93 [0.56, 1.54]

0.77

0.76 [0.46, 1.27]

0.34

0.87 [0.65, 1.14]

0.31

0.94 [0.72, 1.22]

0.63

7.7%

IL-1α rs1800587

Overall

4

822

714

1.08 [0.75, 1.55]

0.67

1.19 [0.44, 3.17]

0.73

1.02 [0.81, 1.29]

0.84

0.99 [0.64, 1.54]

0.98

1.01 [0.64, 1.61]

0.96

14.1%

HTG

3

372

547

1.15 [0.71, 1.86]

0.57

1.51 [0.83, 2.73]

0.18

1.19 [0.87, 1.62]

0.27

1.17 [0.71, 1.91]

0.54

1.41 [0.80, 2.50]

0.23

24.7%

non-HTG

3

450

547

1.84 [0.67, 1.05]

0.12

0.59 [0.32, 1.10]

0.10

0.87 [0.66, 1.16]

0.34

0.87 [0.62, 1.23]

0.44

0.66 [0.36, 1.21]

0.18

35.7%

IL-1β rs1143634

Overall

4

798

730

1.32 [0.99, 1.75]

0.06

1.64 [0.53, 5.11]

0.39

1.32 [0.96, 1.81]

0.09

1.34 [0.98, 1.82]

0.07

1.56 [0.50, 4.84]

0.44

51.1%

HTG

2

216

380

1.61 [1.06, 2.42]

0.02

2.21 [0.48, 10.10]

0.31

1.65 [1.03, 2.65]

0.04

1.69 [1.07, 2.67]

0.03

1.97 [0.43, 8.95]

0.38

73.3%

non-HTG

3

524

625

1.10 [0.79, 1.53]

0.57

1.45 [0.42, 5.07]

0.56

1.07 [0.74, 1.54]

0.72

1.09 [0.76, 1.55]

0.64

1.42 [0.41, 4.93]

0.59

9.4%

  1. HTG high tension glaucoma
  2. aPower calculations were performed for “Allele models”
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