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Table 2 Summary of baseline assessments and procedures in order of conduct

From: Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye

• Inclusion criteria and authorization

 

• Medical and ophthalmic history

 

• Concomitant medications review

 

• Adverse event review

 

• OSDI questionnaire

 

• Dry Eye Patient Survey

 

• Blurred/Fluctuating Vision Assessment

 

• Work Productivity and Activity Impairment Questionnaire

 

• Best-corrected visual acuity

 

• Reading Speed Assessment

 

• Tear collection

 

• Biomicroscopy

 

• Tear break-up time

 

• Corneal staining (with fluorescein)

 

• Conjunctival staining (with lissamine green)

 

• Schirmer’s test (with anesthesia)

 

• Goblet cell density (by impression cytology)

 

• Dispense patient diary