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Table 1 Demographic and clinical characteristics, including corneal biomechanical properties and optic nerve head parameters

From: Relationship between corneal biomechanical properties and structural biomarkers in patients with normal-tension glaucoma: a retrospective study

 

Normal controls

NTG patients

P value

  

Early

Advanced

 

Subjects (n)

93

48

47

 

Age (years)

56.35 ± 10.46

53.92 ± 12.03

62.38 ± 11.96

<0.001a

Gender (male/female)

52 / 41

22 / 26

32 / 15

0.009b

Axial length (mm)

23.79 ± 0.88

23.78 ± 0.91

23.96 ± 1.24

0.590c

GAT (mmHg)

14.97 ± 2.53

15.10 ± 3.18

15.17 ± 2.99

0.874a

CCT (μm)

550.84 ± 26.84

551.29 ± 33.45

544.66 ± 33.62

0.465c

Spherical equivalent (diopter)

−0.50 ± 1.68

−0.43 ± 1.61

−0.59 ± 1.95

0.891a

Visual field

 MD (dB)

−1.57 ± 1.57

−3.10 ± 1.59

−12.63 ± 5.63

<0.001a

 VFI (%)

98.67 ± 1.74

94.21 ± 4.37

67.17 ± 21.49

<0.001a

 PSD (dB)

1.93 ± 0.80

3.84 ± 2.36

9.72 ± 3.97

<0.001a

ORA parameters (mm Hg)

 CH

10.83 ± 1.60

10.56 ± 1.44

9.78 ± 1.52

0.001c

 CRF

10.67 ± 1.88

10.16 ± 1.84

9.67 ± 1.34

0.008a

 IOPg

15.15 ± 3.96

14.21 ± 3.60

14.79 ± 3.51

0.373c

 IOPcc

15.22 ± 3.70

14.69 ± 3.06

16.05 ± 3.93

0.183c

HRT parameters

 Linear cup-to-disc ratio

0.62 ± 0.15

0.69 ± 0.12

0.72 ± 0.13

<0.001a

 Rim area (mm2)

1.57 ± 0.47

1.10 ± 0.28

0.98 ± 0.28

<0.001a

 Rim volume (mm3)

0.38 ± 0.19

0.26 ± 0.12

0.20 ± 0.10

<0.001a

 Mean RNFL thickness (mm)

0.23 ± 0.09

0.20 ± 0.08

0.16 ± 0.11

0.001a

  1. aKruskal–Wallis test, b χ2 test, c one-way ANOVA test
  2. CCT Central corneal thickness, CH Corneal hysteresis, CRF Corneal resistance factor, GAT Goldmann applanation tonometry, HRT Heidelberg Retina Tomograph, IOPg Goldmann-correlated intraocular pressure, IOPcc Corneal-compensated intraocular pressure, MD Mean deviation, NTG Normal tension glaucoma, 0 Ocular Response Analyzer, PSD Pattern standard deviation, RNFL Retinal nerve fibre layer, VFI Visual field index