Elevated inflammatory cytokines in aqueous cytokine profile in HIV-1 infected patients with cataracts in Uganda

BMC Ophthalmology

Table 3 Cytokine levels among patients that had cataract surgery at RHSP, south-western Uganda

	HIV+		HIV -		P-value at α = 0.05*	P-value at α = 0.00625^§
Cytokine	Median (IQR)		Median (IQR)		P-value at α = 0.05*	P-value at α = 0.00625^§
IL-6	1396	[432, 3999]	727	[371, 1338]	0.180	0.180
IFN-g	753	[154, 1783]	154	[154, 1315]	0.488	0.488
GM-CSF	1850	[1632, 1948]	1399	[1037, 1681]	0.001*	0.001^§
TNF-a	79	[42, 167]	42	[6, 122]	0.152	0.152
IL-2	78	[25 , 147]	50	[25, 111]	0.445	0.445
IL-4	9	[9, 44]	21	[9, 40]	0.887	0.887
IL-8	499	[409, 1648]	397	[291, 573]	0.030*	0.030
IL-10	243	[209, 369]	146	[72, 175]	0.000*	0.000^§

*Significant at α = 0.05
^§Significant at α = 0.00625 corrected with Bonferroni correction for multiple comparisons
GM-CSF, IL-8 and IL-10 were found in significantly higher levels in the HIV positive group compared to the HIV negative group
IL-6 Interleukin 6, IFN-g Interferon –gamma, GM-CSF Granulocyte macrophage colony stimulating factor, TNF-a Tumour necrosis factor alpha, IL-2 Interleukin 2, IL-4 Interleukin 4, IL-8 Interleukin 8, IL-10 Interleukin 10, RHSP Rakai Health Service Programme

ISSN: 1471-2415