Elevated inflammatory cytokines in aqueous cytokine profile in HIV-1 infected patients with cataracts in Uganda

BMC Ophthalmology

Table 4 Cytokine levels in categorized HIV infected individuals on ART treatment that had cataract surgery at RHSP, south-western Uganda

	On ART		Not on ART		P-value at α = 0.05*	P-value at α = 0.00625^§
	Median (IQR)		Median (IQR)		P-value at α = 0.05*	P-value at α = 0.00625^§
IL-6	3092	[540, 9366]	763	[381, 1813]	0.124	0.124
IFN-g	1410	[784, 3230]	453	[154, 753]	0.115	0.115
GM-CSF	1893	[1632, 1975]	1791	[1451, 1890]	0.002*	0.002^§
TNF-a	95	[61, 299]	79	[6, 136]	0.255	0.255
IL-2	98	[33, 223]	64	[25, 127]	0.530	0.530
IL-4	32	[9, 77]	9	[9, 26]	0.245	0.245
IL-8	1364	[419, 2573]	443	[389, 585]	0.021*	0.021
IL-10	273	[232, 497]	215	[184, 292]	0.000*	0.000^§

*Significant at α = 0.05
^§Significant at α = 0.00625 corrected with Bonferroni correction for multiple comparisons
Pro-inflammatory cytokine (GM-CSF, IL-8 and IL-10) were found at significantly higher levels among HIV patients on ART
IL-6 Interleukin 6, IFN-g Interferon –gamma, GM-CSF Granulocyte macrophage colony stimulating factor, TNF-a Tumour necrosis factor alpha, IL-2 Interleukin 2, IL-4 Interleukin 4, IL-8 Interleukin 8, IL 10 Interleukin 10, IQR Interquartile range, RHSP Rakai Health Service Programme, ART Antiretroviral therapy (zidovudine, lamivudine and nevirapine)

ISSN: 1471-2415