Skip to main content

Table 1 Microarray analysis of retinal genes upregulated 5-fold and higher 4 h postinfection with B. cereus ATCC14579

From: TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis

Gene symbol Gene title RefSeq Transcript ID Fold-Change
(C57BL6/J infected versus uninfected)
p-value Fold-Change
(TLR4−/− infected versus uninfected)
p-value
CXCL1 chemokine (C-X-C motif) ligand 1 NM_008176 34 0.0106 NC NS
CXCL2 chemokine (C-X-C motif) ligand 2 NM_009140 29 0.0225 NC NS
IL-6 interleukin 6 NM_031168 25 0.0114 NC NS
CXCL10 chemokine (C-X-C motif) ligand 10 NM_021274 21 0.0328 NC NS
CCL2 chemokine (C-C motif) ligand 2 NM_011333 20 0.0355 NC NS
CCL3 chemokine (C-C motif) ligand 3 NM_011337 16 0.0006 5 0.0446
PTX3 pentraxin related gene NM_008987 15 0.0376 NC NS
ICAM1 intercellular adhesion molecule 1 NM_010493 11 0.0026 NC NS
SOCS3 suppressor of cytokine signaling 3 NM_007707 10 0.0034 NC NS
CYR61 cysteine rich protein 61 NM_010516 10 0.0116 NC NS
MOBP myelin-associated oligodendrocytic basic protein NM_008614 NC NS 10 0.0270
MBP myelin basic protein NM_001025245 NC NS 10 0.0223
PTGS2 prostaglandin-endoperoxide synthase 2 NM_011198 9 0.0027 NC NS
STEAP4 STEAP family member 4 NM_054098 6 0.0116 NC NS
LIF leukemia inhibitory factor NM_008501 6 0.0055 NC NS
CH25H cholesterol 25-hydroxylase NM_009890 6 0.0232 NC NS
PLP1 proteolipid protein (myelin) 1 NM_011123 NC NS 6 0.0236
EGR2 early growth response 2 NM_010118 5 0.0062 NC NS
  1. The fold changes of retinal genes in C57BL6/J mouse eyes and TLR4−/− mouse eyes after infection relative to the uninfected, contralateral eye are shown. Levels of significance were determined using ANOVA and p < 0.05 was considered significant
  2. NC no change, NS not significant