Association between blood pressure and retinal arteriolar and venular diameters in Chinese early adolescent children, and whether the association has gender difference: a cross-sectional study

He, Yuan; Li, Shi-Ming; Kang, Meng-Tian; Liu, Luo-Ru; Li, He; Wei, Shi-Fei; Ran, An-Ran; Wang, Ningli

doi:10.1186/s12886-018-0799-x

Table 5 Subgroup analysis stratified by potential effect modifiers of retinal Venular Diameter with BP, stratified by potential modifiers

From: Association between blood pressure and retinal arteriolar and venular diameters in Chinese early adolescent children, and whether the association has gender difference: a cross-sectional study

Potential Effect Modifiers			n	Retinal Venular Diameter (μm)
			n	Model 1	p	Model 2	P	Model 3	P
SBP	Age	10 + 11	70	0.40 ± 2.16	0.855	1.43 ± 1.99	0.476	1.78 ± 1.71	0.302
		12	1122	−2.1 ± 0.55	< 0.001	−2.52 ± 0.54	<.001	−0.73 ± 0.50	0.148
		13 + 14 + 15	309	− 0.53 ± 1.08	0.622	−1.61 ± 1.06	0.129	0.02 ± 0.94	0.986
	Sex	Male	792	−1.12 ± 0.66	0.092	−2.03 ± 0.65	0.002	0.14 ± 0.57	0.809
	Sex	Female	709	−1.72 ± 0.69	0.013	−2.15 ± 0.68	0.002	−0.85 ± 0.64	0.186
	BMI	Upper 50%	750	−1.66 ± 0.75	0.028	−2.11 ± 0.69	0.002	−0.84 ± 0.64	0.186
	BMI	Lower 50%	751	−2.67 ± 0.69	< 0.001	−2.13 ± 0.64	0.001	0.06 ± 0.58	0.923
	Birth weight	Upper 50%	778	−1.97 ± 0.68	0.004	−2.05 ± 0.67	0.002	−0.27 ± 0.61	0.654
	Birth weight	Lower 50%	723	−1.19 ± 0.67	0.074	−2.06 ± 0.66	0.002	−0.43 ± 0.61	0.478
	Gestational age	Term	1372	−1.61 ± 0.5	0.001	−2.19 ± 0.49	<.001	−0.46 ± 0.45	0.309
	Gestational age	Preterm	129	−1.13 ± 1.55	0.467	−0.88 ± 1.64	0.594	0.62 ± 1.53	0.688
DBP	Age	10 + 11	70	2.59 ± 2.64	0.330	2.16 ± 2.42	0.376	2.62 ± 2.08	0.213
		12	1122	−2.42 ± 0.79	0.002	−2.91 ± 0.72	<.001	−0.31 ± 0.67	0.648
		13 + 14 + 15	309	0.3 ± 1.45	0.838	−2.33 ± 1.36	0.089	−0.92 ± 1.20	0.442
	Sex	Male	792	−1.11 ± 0.94	0.239	−2.38 ± 0.86	0.006	0.60 ± 0.76	0.433
	Sex	Female	709	−1.96 ± 0.96	0.042	−2.35 ± 0.86	0.007	−0.69 ± 0.82	0.4
	BMI	Upper 50%	750	−1.42 ± 0.99	0.151	−2.12 ± 0.89	0.017	−0.10 ± 0.82	0.907
	BMI	Lower 50%	751	−2.11 ± 0.95	0.026	−2.46 ± 0.84	0.004	0.07 ± 0.76	0.93
	Birth weight	Upper 50%	778	−1.47 ± 0.93	0.112	−1.98 ± 0.84	0.018	0.18 ± 0.76	0.811
	Birth weight	Lower 50%	723	−1.48 ± 0.98	0.132	−2.65 ± 0.90	0.003	−0.28 ± 0.83	0.733
	Gestational age	Term	1372	−1.59 ± 0.71	0.024	−2.37 ± 0.64	<.001	−0.15 ± 0.58	0.798
	Gestational age	Preterm	129	−0.02 ± 2.2	0.994	−2.43 ± 2.23	0.278	0.18 ± 2.12	0.931
MABP	Age	10 + 11	70	1.92 ± 2.65	0.469	2.13 ± 2.41	0.38	2.61 ± 2.07	0.213
		12	1122	−2.75 ± 0.76	< 0.001	−3.32 ± 0.71	<.001	− 0.59 ± 0.67	0.38
		13 + 14 + 15	309	− 0.12 ± 1.43	0.933	−2.48 ± 1.37	0.072	−0.62 ± 1.21	0.609
	Sex	Male	792	−1.34 ± 0.89	0.133	−2.68 ± 0.85	0.002	0.47 ± 0.75	0.535
	Sex	Female	709	−2.25 ± 0.94	0.017	−2.76 ± 0.88	0.002	−0.90 ± 0.84	0.284
	BMI	Upper 50%	750	−1.89 ± 0.99	0.056	−2.63 ± 0.89	0.003	−0.55 ± 0.83	0.513
	BMI	Lower 50%	751	−2.85 ± 0.93	0.002	−2.74 ± 0.83	0.001	0.13 ± 0.76	0.868
	Birth weight	Upper 50%	778	−2.13 ± 0.91	0.020	−2.52 ± 0.86	0.003	−0.02 ± 0.78	0.978
	Birth weight	Lower 50%	723	−1.55 ± 0.92	0.093	−2.80 ± 0.87	0.001	−0.38 ± 0.81	0.643
	Gestational age	Term	1372	−1.94 ± 0.68	0.004	−2.78 ± 0.64	<.001	−0.33 ± 0.59	0.577
	Gestational age	Preterm	129	−0.72 ± 2.13	0.736	−2.07 ± 2.18	0.345	0.49 ± 2.07	0.812

Model 1:unadjusted model; Model 2: adjusted for age, gender, axial length, BMI, waist, spherical equivalent, birth weight and gestational age; Model 3: adjusted for fellow vessel diameter additionally. SBP systolic blood pressure, DBP diastolic blood pressure, MABP mean arterial blood pressure. Term means pregnancy lasts longer than 37 weeks, and preterm represents that the duration of pregnancy is less than 37 weeks.Significant p values are bolded

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