Fig. 6
From: The effects of local administration of mesenchymal stem cells on rat corneal allograft rejection
Cytokine expression in corneal allografts. At day 7, IL-4 and IL-10 mRNA expression in MSCs-treated groups was significantly higher than in controls (c, d). MSCs treatment also reduced IFN-γ mRNA expression (a). At day 10, grafts receiving MSCs treatment maintained higher IL-4 and IL-10 mRNA expression (c, d), but lower IFN-γ and IL-2 mRNA expression (a, b). Collectively, the Th1/Th2 ratio was reduced in MSCs-treated grafts in this corneal rejection model. Cytokine IL-10 expression was evaluated using ELISA (e). At day 10, IL-10 levels were significantly increased in mesenchymal stem cell-treated grafts when compared with untreated grafts and normal cornea (F = 142.92, p < 0.05)