Table 2 Univariate analysis for various factors related to overall survival (OS)
Characteristic | survival | P value | ||||
|---|---|---|---|---|---|---|
n/N | Median survival time (years) | 1 year (%) | 3 years (%) | 5 years (%) | ||
Overall rate | 22/39 | 3.89 | 69.1 | 50.5 | 41.2 | |
Gender | ||||||
Male | 11/21 | 5.11 | 71.4 | 60.3 | 46.5 | 0.269 |
Female | 11/18 | 1.34 | 66.2 | 19.3 | 19.3 | |
Mean age (years) | ||||||
≤ 63 | 11/18 | 1.65 | 55.0 | 40.1 | 30.0 | 0.516 |
> 63 | 11/21 | 5.35 | 76.2 | 51.9 | 41.5 | |
Mean duration of presenting symptom (weeks) | ||||||
≤ 67.9 | 16/26 | 3.89 | 65.2 | 51.8 | 41.5 | 0.967 |
> 67.9 | 6/13 | 1.70 | 69.2 | 48.5 | 48.5 | |
Restriction of extraocular movements | ||||||
No | 4/10 | 5.35 | 90.0 | 75.0 | 56.0 | 0.093 |
Yes | 18/29 | 1.65 | 58.0 | 36.2 | 29.0 | |
Mass | ||||||
No | 6/13 | 5.35 | 69.2 | 29.7 | 29.7 | 0.965 |
Yes | 16/26 | 3.01 | 69.2 | 49.0 | 37.8 | |
Eye pain on presentation | ||||||
No | 13/23 | 3.01 | 69.6 | 55.8 | 42.5 | 0.646 |
Yes | 9/16 | 3.89 | 68.8 | 40.1 | 20.1 | |
VA | ||||||
≥ 20/400 | 3/12 | 10.1 | 91.7 | 68.8 | 68.8 | 0.018* |
< 20/400 | 18/26 | 1.65 | 57.4 | 38.1 | 30.5 | |
Tumor size | ||||||
≤ 20 mm | 4/13 | 11.95 | 76.2 | 67.7 | 67.7 | 0.032* |
> 20 mm | 18/26 | 1.65 | 65.4 | 41.4 | 27.6 | |
Histopathologic diagnosis | ||||||
Non-squamous cell carcinoma | 15/25 | 3.01 | 63.8 | 43.8 | 37.6 | 0.528 |
Squamous cell carcinoma | 7/14 | 5.35 | 78.6 | 50.3 | 25.1 | |
Tumor origin | ||||||
Lid | 6/12 | 3.01 | 83.3 | 44.4 | 22.2 | 0.660 |
Lacrimal, globe, and orbit | 8/14 | 0.85 | 50.0 | 40.0 | 40.0 | |
Conjunctiva | 8/13 | 5.11 | 69.2 | 52.8 | 39.6 | |
Surgical margins | ||||||
Unclear margin | 7/14 | 5.45 | 71.4 | 52.1 | 39.1 | 0.597 |
Clear margin | 15/25 | 3.89 | 68.0 | 44.1 | 35.3 | |
Tumor invasiveness (lymphovascular, perineural, bony) | ||||||
No | 15/29 | 3.89 | 65.5 | 48.6 | 41.7 | 0.453 |
Yes | 7/10 | 3.01 | 80.0 | 40.0 | 20.0 | |
Status of metastasis | ||||||
No distant metastasis | 9/23 | 5.45 | 91.3 | 70.6 | 62.8 | < 0.001* |
Regional nodal metastasis | 3/5 | 3.01 | 60.0 | 60.0 | 0.0 | |
Distant metastasis | 10/11 | 0.59 | 24.2 | 0.0 | 0.0 | |
Adding resection | ||||||
No | 18/33 | 3.89 | 63.5 | 47.9 | 41.9 | 0.815 |
Yes | 4/6 | 3.01 | 83.3 | 33.3 | 0.0 | |
Radiation | ||||||
No | 12/22 | 3.89 | 72.7 | 52.0 | 36.4 | 0.579 |
Yes | 10/17 | 5.11 | 64.7 | 37.8 | 37.8 | |
Chemotherapy | ||||||
No | 16/31 | 3.89 | 77.3 | 53.5 | 41.3 | 0.197 |
Yes | 6/8 | 0.65 | 37.5 | 18.8 | 18.8 | |
Recurrent disease | ||||||
No | 16/32 | 5.35 | 74.9 | 55.5 | 44.1 | 0.043* |
Yes | 6/7 | 0.85 | 28.6 | 0.0 | 0.0 | |