Association of Genes implicated in primary angle-closure Glaucoma and the ocular biometric parameters of anterior chamber depth and axial length in a northern Chinese population

Table 4 Associations for target SNPs between cases and controls in different ethnicities as well as the meta-analysis results

SNP	MAF-case		MAF-control		OR (95% CI)		p		P-meta ^a	I²	P-het
SNP	HUI	HAN	HUI	HAN	HUI	HAN	HUI	HAN	P-meta ^a	I²	P-het
rs7290117	0.06452	0.07617	0.05118	0.06684	2.103 (0.8305~ 5.237)	1.151 (0.7692~ 1.723)	0.1169	0.4937	0.184	21.57	0.2588
rs2179129	0.4409	0.3956	0.4488	0.4272	0.877 (0.5951~ 1.293)	0.9251 (0.7511~ 1.139)	0.5073	0.4638	0.3643	0	0.7915
rs4823006	0.457	0.4951	0.4882	0.4509	0.9995 (0.667~ 1.498)	1.194 (0.9665~ 1.475)	0.998	0.1002	0.1359	0	0.4326
rs3178915	0.3925	0.4261	0.4252	0.3947	0.9102 (0.5945~ 1.394)	1.123 (0.9105~ 1.385)	0.6652	0.2783	0.4353	0	0.3858
rs5745718	0.1022	0.1536	0.1732	0.1261	0.573 (0.3114~ 1.054)	1.061 (0.784~ 1.435)	0.07339	0.7022	0.5334	68.41	0.0752
rs12536657	0.1022	0.1564	0.1732	0.128	0.5612 (0.3048~ 1.033)	1.074 (0.7944~ 1.452)	0.06371	0.6423	0.5369	71.26	0.0621
rs12540393	0.1183	0.1835	0.2087	0.143	0.5067 (0.2872~ 0.8939)	1.077 (0.8089~ 1.433)	0.01892	0.6131	0.4807	81.32	0.0207
rs17427817	0.1183	0.1843	0.2087	0.1438	0.5067 (0.2872~ 0.8939)	1.069 (0.8035~ 1.421)	0.01892	0.6485	0.4782	81.23	0.021
rs3735520	0.4839	0.4595	0.4094	0.4492	1.375 (0.9151~ 2.065)	1.158 (0.9402~ 1.426)	0.1254	0.1675	0.05236	0	0.4662
rs2510143	0.172	0.129	0.2047	0.1455	0.7626 (0.4533~ 1.283)	0.872 (0.6455~ 1.178)	0.3072	0.3722	0.2059	0	0.6545
rs36015759	0.2581	0.2408	0.1969	0.2437	1.526 (0.938~ 2.481)	1.005 (0.7954~ 1.27)	0.08872	0.9671	0.4457	57.53	0.1249
rs3814762	0.1452	0.2039	0.1693	0.1912	0.7363 (0.412~ 1.316)	0.988 (0.7692~ 1.269)	0.3014	0.9249	0.6413	0	0.3552

MAF minor allele frequency, OR odds ratio, CI confidence interval, I² measures heterogeneity, p-het p-value for heterogeneit;
P-value, OR, and CI were calculated with a logistic regression model by adjusting for age and sex
^aP-meta, P-value obtained by meta-analysis, if the I² value was ≥50%, we took the value of random-effects; otherwise, a fixed-effects model was adopted

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