Fig. 4

En face optical coherence tomography angiography and corresponding cross-sectional optical coherence tomography angiography with flow signals of polypoidal choroidal vasculopathy in case 2. Prior to combination therapy of intravitreal injection of ranibizumab (IVR) and photodynamic therapy (PDT), en face optical coherence tomography angiography (OCT-A) shows the branching vascular network (BVN) and a polyp (yellow arrow) (a). A corresponding cross-sectional OCT-A demonstrates the pigment epithelium detachment (PED) to contain flow signals (red dots indicated by yellow arrow) at the position of the polyp (b). OCT-A 2 weeks after PDT shows marked regression of both the BVN and polyp (yellow arrow) (c), which can be confirmed in cross-sectional OCT-A depicting a flattened PED devoid of flow signals (d). Two months after PDT, the BVN has restored most of its original network observed in (a) while the polyp remains absent (yellow arrow) (e). In cross-sectional OCT-A at 2 months, the PED shows mild restoration of height but flow signals are still minimal (f)