Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies

Table 2 Meta-analysis of the association between rs5498 and DR in type 2 diabetes

Evaluation	Number of studies	OR (95% CI)	P	P for heterogeneity	I² (%)
GA + GG versus AA
Total	9	1.00 (0.66–1.50)	0.987	< 0.001	84.0
Asians	8	0.96 (0.61–1.50)	0.843	< 0.001	85.2
Caucasians	1	1.40 (0.86–2.27)	0.173	NA	NA
PDR	4	1.22 (0.61–2.47)	0.577	< 0.001	86.8
NPDR	3	0.60 (0.29–1.21)	0.151	0.007	80.0
GG versus GA + AA
Total	9	1.24 (0.86–1.77)	0.245	0.003	65.3
Asians	8	1.15 (0.79–1.68)	0.469	0.008	63.2
Caucasians	1	2.00 (1.15–3.48)	0.014	NA	NA
PDR	4	1.90 (0.80–4.50)	0.146	< 0.001	84.2
NPDR	3	0.92 (0.58–1.47)	0.724	0.477	0.0
GG versus AA
Total	9	1.14 (0.68–1.92)	0.611	< 0.001	78.5
Asians	8	1.04 (0.60–1.81)	0.887	< 0.001	78.1
Caucasians	1	2.21 (1.16–4.22)	0.016	NA	NA
PDR	4	1.91 (0.64–5.73)	0.246	< 0.001	87.6
NPDR	3	0.77 (0.47–1.25)	0.286	0.171	43.5
G allele versus A allele
Total	9	1.08 (0.81–1.45)	0.592	< 0.001	85.7
Asians	8	1.05 (0.76–1.44)	0.790	< 0.001	86.3
Caucasians	1	1.44 (1.06–1.95)	0.021	NA	NA
PDR	4	1.34 (0.71–2.52)	0.364	< 0.001	82.5
NPDR	3	0.71 (0.43–1.17)	0.180	0.011	77.9

CI confidence interval, DR diabetic retinopathy, NA not applicable, NPDR non-proliferative diabetic retinopathy, OR odds ratio, PDR proliferative diabetic retinopathy

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