Fig. 2

A representative case of circumscribed choroidal hemangioma showing the change in retinal fluid over time. A 48-year-old woman (Case 7) presented with blurred vision of the right eye. Her initial best corrected visual acuity (BCVA) was 0.63. (a) On fundus photography, an orange and red-colored subretinal mass was observed supero-temporally to the macula. (b) B-scan ultrasonography showed a hyperreflective mass with a height of 4.77 mm and base diameter of 11.07 mm. (c) Shallow subretinal fluid involving the fovea was observed along with elevation of the choroid by a mass lesion on optical coherence tomography. (d) During the first 6 months, despite a single intravitreal bevacizumab (IVB) injection, the subretinal fluid (SRF) increased. Thereafter, a second IVB injection and single session of transpupillary thermotherapy (TTT) were performed; however, there was no significant improvement in therapeutic effect. Subsequently, a single session of photodynamic therapy (PDT) and enhanced PDT were performed and the SRF completely resolved. However, the subsequent BCVA was 0.04. (e) After 2 years of follow-up, SRF and intraretinal fluid then developed. (f) Six months later, an advanced cystoid macular edema pattern was observed