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Table 3 Optic Nerve Head and Retinal Nerve Fiber Layer Parameters by Disease Stage

From: Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study

Parametersa Control Group (n = 34) Mild Glaucoma (n = 14) Moderate Glaucoma (n = 13) Advanced Glaucoma (n = 12) P Value
PLNT area, mm2 0.65 ± 0.17 0.38 ± 0.1 0.32 ± 0.08 0.26 ± 0.07 <.001b
Average pRNFL thickness, μm 101.1 ± 14.3 71.3 ± 11.1 65.9 ± 10.2 57.5 ± 12.8 <.001c
ALD, μm 413.3 ± 109.1 476.4 ± 98.1 494.9 ± 162.3 462.1 ± 164.4 .177
Average BMO-MRW, μm 328.6 ± 55.2 181.5 ± 35.2 167.6 ± 45.6 106.1 ± 38.4 <.001d
  1. Abbreviations: ALD Anterior lamina depth, BMO-MRW Bruch’s membrane opening-minimum rim width, PLNT Prelaminar neural tissue, pRNFL Peripapillary retinal nerve fiber layer
  2. aData are given as mean ± SD
  3. bEach glaucoma group differed significantly from controls, but there was no significant difference between the glaucoma groups
  4. cEach glaucoma group differed significantly from controls. There was also a significant difference between eyes with mild and advanced glaucoma
  5. dEach glaucoma group differed significantly from controls. There were also significant differences between eyes with mild and advanced glaucoma, and between eyes with moderate and advanced glaucoma