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Table 3 Results of analyses by disease

From: Retinal function determined by flicker ERGs before and soon after intravitreal injection of anti-VEGF agents

3–1. ERG responses before and after injection in eyes with AMD

AMD n = 37 (male, 24; female, 13)

mean age

74.1 ± 8.6 y.o.

   

injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

29.9 ± 1.8

30.4 ± 1.6a

30.8 ± 2.14a

p = 0.00009

(msec.)

 

p = 0.025

p = 0.00001

amplitude

9.0 ± 5.7

8.1 ± 6.4

9.0 ± 6.3

p = 0.484

(uV)

 

p = 1

p = 1

non-injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

29.5 ± 2.5

30.4 ± 2.1a

30.6 ± 2.4a

p = 0.00097

(msec.)

 

p = 0.023

p = 0.0017

amplitude

10.1 ± 7.2

9.6 ± 7.3

9.8 ± 6.2

p = 0.853

(uV)

 

p =1 

p =1 

3–2. ERG responses before and after injection in eyes with DME

DME n = 24 (male, 14; female, 10)

mean age

59.9 ± 11.3 y.o.

injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

33.6 ± 3.2

34.2 ± 3.2

34.7 ± 3.1a

p = 0.00036

(msec.)

 

p = 0.19

p = 0.0003

Amplitude

8.0 ± 5.9

7.1 ± 5.8

7.6 ± 5.9

p = 0.45

(uV)

 

p = 0.94

p = 0.96

non-injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

33.6 ± 3.1

34.1 ± 3.1

34.3 ± 3.4a

p = 0.0493

(msec.)

 

p = 0.327

p = 0.014

Amplitude

7.5 ± 5.1

7.2 ± 5.5

7.8 ± 5.6

p = 0.495

(uV)

 

p = 1

p = 1

3–3. ERG responses before and after injection in eyes with ME associated with RVO

RVO with ME n = 18 (male, 6; female, 12)

mean age

70.1 ± 14.9 y.o.

injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

30.7 ± 3.7

31.3 ± 3.4

31.6 ± 3.79a

p = 0.00692

(msec.)

 

p = 0.1125

p = 0.0027

Amplitude

8.9 ± 5.7

8.5 ± 5.8

12.9 ± 14.7

p = 0.214

(uV)

 

p = 1

p = 0.68

non-injected eye

Phase 1

Phase 2

Phase 3

repeated measure test

implicit time

28.4 ± 1.9

28.6 ± 2.0

28.9 ± 2.3

p = 0.231

(msec.)

 

p = 0.85

p = 0.53

amplitude

10.5 ± 6.4

10.8 ± 6.5

11.2 ± 6.7

p = 0.573

(uV)

 

p = 1

p = 0.96

  1. The results of 28 Hz flicker electroretinogram components classified by disease. The ERGs were recorded before the injection (Phase 1), within 2 h after the injection (Phase 2), and 2 to 24 h after the injection (Phase 3)
  2. mean ± standard deviation
  3. a; significant difference by the repeated measure test and by the post hoc test compared with Phase 1
  4. AMD age-related macular degeneration;
  5. DME diabetic macular edema;
  6. RVO with ME retinal vein occlusion with macular edema
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BMC Ophthalmology

ISSN: 1471-2415

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