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Fig. 4 | BMC Ophthalmology

Fig. 4

From: Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-A/PI3K/Akt pathway

Fig. 4

The mechanistic diagram of NGF and ILM-mediated proliferation promotion by regulating cell cycle of Müller cells. ILM co-culture enhanced the activity of Akt independent of Trk-A and the downstream p21-CyclinE-CDK2 and CyclinD1-CDK4 signaling pathways, leading to cell cycle and cell growth enhancement. NGF exposure mediated the activation of Trk-A and further promoted the upregulation of the PI3K/Akt pathway followed by the increase of CyclinD1-CDK4, and by the decrease of p21 and CyclinE-CDK2 kinase complex activities, which then induced cell cycle progression and cell growth promotion in Müller cells

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BMC Ophthalmology

ISSN: 1471-2415

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