Diagnostic accuracy of optical coherence tomography angiography for choroidal neovascularization: a systematic review and meta-analysis

Table 1 Major characteristics of included studies

Author	Year	Tp	Fp	Fn	Tn	Country	Ethnicity	Type of study	Etiology	Reference image	Type of CNV	Device
Moult E	2014	16	0	1	63	USA	Caucasian	Prospective	AMD	FA,ICGA	NA	VCSEL
Lupidi M	2015	4	0	1	20	France	Caucasian	Retrospective	AOFVD	FA,ICGA,OCT	NA	Spectralis
Bonini Filho MA	2015	8	0	0	19	USA	Mixed	Prospective	CSCR	FA	Type1, mixed type 1/2	AngioVue
de Carlo TE	2015	4	2	4	20	USA	Mixed	Retrospective	Multiple1	FA	NA	AngioVue
Shaimov TB	2015	33	1	4	14	Russia	Caucasian	Prospective	AMD	FA	Type1,2	AngioVue
Carnevali A	2016	18	0	4	22	Italy	Caucasian	NA	AMD	ICGA	NA	AngioPlex/ Angiovue
Miyata M	2016	16	0	1	4	Japan	Asian	NA	Myopia	FA	Type 2	AngioVue
de Carlo TE	2016	6	1	1	22	USA	Caucasian	Retrospective	CSCR	FA	NA	AngioVue
Gong J	2016	45	11	7	23	China	Asian	Retrospective	AMD	FA	Type1,2,mixed type1/2	AngioVue
Querques L	2017	19	2	2	30	Italy	Caucasian	Retrospective	Myopia	FA,OCT	NA	AngioPlex
Faridi A	2017	32	0	0	40	USA	Caucasian	Prospective	AMD	FA,OCT	NA	AngioVue
Ahmed D	2018	81	0	26	49	Austria	Caucasian	Retrospective	AMD	FA	Type1,2,3,mixed type	Topcon
Nikolopoulou E	2018	44	2	6	18	Italy	Caucasian	Prospective	AMD	FA	Type1,2,3,mixed type1/2	AngioVue
Souedan V	2018	8	1	1	6	France	Caucasian	Retrospective	Multiple2	FA,OCT	All types	AngioVue
Soomro T	2018	32	6	13	26	England	Caucasian	Retrospective	Multiple3	FA	Type1,2	Spectralis
de Oliveira T	2019	9	0	1	12	Brazil	Mixed	NA	Multiple4	FA,ICGA,OCT	NA	AngioVue

Tn True positive, Fp False positive, Fn False negative, Tn True negative, AMD Age-related macular degeneration, AOFVD Adult onset foveomacular vitelliform dystrophy, CSCR Central serous chorioretinopathy, FA Fluorescein angiography, ICGA Indocyanine green angiography, OCT Optical coherence tomography, CNV Choroidal neovascularization
Multiple1 = AMD, CSCR and different diagnosis (angioid streaks, multifocal choroiditis, myopic degeneration, pars planitis, or an unclear diagnosis with the differential diagnosis including CSCR, neo-vascular AMD, or polypoidal choroidal vasculopathy (PCV)
Multiple2 = AMD, reperfused central retinal artery obstruction, one adult onset pseudovitelliform lesion, drusenoid pigment epithelium detachment, CSCR, macroaneurysm and reticular dystrophy
Multiple3 = AMD, PCV, CSCR or pathological myopia
Multiple4 = AMD, PCV and CSCR
VCSEL = OCTA combining vertical cavity surface emitting laser (VCSEL) swept light source OCT with 400 kHz A-scan rate prototype system
Topcon = Topcon OCT-A (Topcon Corporation, Tokyo, Japan)
AngioVue = AngioVue OCT-A (Optovue, Inc., Freemont, CA)
AngioPlex = AngioPlex OCT-A (Carl Zeiss Meditec, Inc., Dublin, USA)
Spectralis = Spectralis OCT-A (Heidelberg Engineering, Heidelberg, Germany)
NA = Not available

ISSN: 1471-2415