Skip to main content


Table 1 Major characteristics of included studies

From: Diagnostic accuracy of optical coherence tomography angiography for choroidal neovascularization: a systematic review and meta-analysis

AuthorYearTpFpFnTnCountryEthnicityType of studyEtiologyReference imageType of CNVDevice
Moult E2014160163USACaucasianProspectiveAMDFA,ICGANAVCSEL
Lupidi M201540120FranceCaucasianRetrospectiveAOFVDFA,ICGA,OCTNASpectralis
Bonini Filho MA201580019USAMixedProspectiveCSCRFAType1, mixed type 1/2AngioVue
de Carlo TE201542420USAMixedRetrospectiveMultiple1FANAAngioVue
Shaimov TB2015331414RussiaCaucasianProspectiveAMDFAType1,2AngioVue
Carnevali A2016180422ItalyCaucasianNAAMDICGANAAngioPlex/ Angiovue
Miyata M201616014JapanAsianNAMyopiaFAType 2AngioVue
de Carlo TE201661122USACaucasianRetrospectiveCSCRFANAAngioVue
Gong J20164511723ChinaAsianRetrospectiveAMDFAType1,2,mixed type1/2AngioVue
Querques L2017192230ItalyCaucasianRetrospectiveMyopiaFA,OCTNAAngioPlex
Faridi A2017320040USACaucasianProspectiveAMDFA,OCTNAAngioVue
Ahmed D20188102649AustriaCaucasianRetrospectiveAMDFAType1,2,3,mixed typeTopcon
Nikolopoulou E2018442618ItalyCaucasianProspectiveAMDFAType1,2,3,mixed type1/2AngioVue
Souedan V20188116FranceCaucasianRetrospectiveMultiple2FA,OCTAll typesAngioVue
Soomro T20183261326EnglandCaucasianRetrospectiveMultiple3FAType1,2Spectralis
de Oliveira T201990112BrazilMixedNAMultiple4FA,ICGA,OCTNAAngioVue
  1. Tn True positive, Fp False positive, Fn False negative, Tn True negative, AMD Age-related macular degeneration, AOFVD Adult onset foveomacular vitelliform dystrophy, CSCR Central serous chorioretinopathy, FA Fluorescein angiography, ICGA Indocyanine green angiography, OCT Optical coherence tomography, CNV Choroidal neovascularization
  2. Multiple1 = AMD, CSCR and different diagnosis (angioid streaks, multifocal choroiditis, myopic degeneration, pars planitis, or an unclear diagnosis with the differential diagnosis including CSCR, neo-vascular AMD, or polypoidal choroidal vasculopathy (PCV)
  3. Multiple2 = AMD, reperfused central retinal artery obstruction, one adult onset pseudovitelliform lesion, drusenoid pigment epithelium detachment, CSCR, macroaneurysm and reticular dystrophy
  4. Multiple3 = AMD, PCV, CSCR or pathological myopia
  5. Multiple4 = AMD, PCV and CSCR
  6. VCSEL = OCTA combining vertical cavity surface emitting laser (VCSEL) swept light source OCT with 400 kHz A-scan rate prototype system
  7. Topcon = Topcon OCT-A (Topcon Corporation, Tokyo, Japan)
  8. AngioVue = AngioVue OCT-A (Optovue, Inc., Freemont, CA)
  9. AngioPlex = AngioPlex OCT-A (Carl Zeiss Meditec, Inc., Dublin, USA)
  10. Spectralis = Spectralis OCT-A (Heidelberg Engineering, Heidelberg, Germany)
  11. NA = Not available