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Table 2 Baseline characters of studies

From: Corneal biomechanical properties after SMILE versus FLEX, LASIK, LASEK, or PRK: a systematic review and meta-analysis

First author

Publication year

Study location

Study design

Follow-up (months)

Group

N (eye) at baseline

Age (year) Mean ± SD

SE (D) Mean ± SD

CCT (μm) Mean ± SD

IOP (mmHg) Mean ± SD

Anders H. Vestergaard [45, 46]

2014/2019

Denmark

RCT

6

SMILE

34

35.00 ± 7.00

−7.65 ± 1.11

552.00 ± 30.00

16.10 ± 3.00

     

FLEX

34

35.00 ± 7.00

−7.59 ± 0.97

553.00 ± 28.00

15.80 ± 2.80

Danyang Wang [47]

2014

China

Prospective cohort

3

SMILE (SE ≤

−6.00D)

124

24.85 ± 4.34

−4.45 ± 1.00

553.57 ± 25.50

15.75 ± 3.12

     

FS-LASIK (SE ≤-6.00D)

49

25.47 ± 3.71

−4.24 ± 1.40

547.49 ± 35.00

14.79 ± 2.87

     

SMILE (SE >

−6.00D)

63

24.70 ± 4.68

−7.38 ± 0.95

556.00 ± 26.91

16.97 ± 2.78

     

FS-LASIK (SE >

−6.00D)

30

23.73 ± 3.94

−7.60 ± 1.04

539.43 ± 34.23

16.17 ± 3.23

Iben Bach Pedersen [48]

2014

Denmark

Cross-sectional

16

SMILE

29

40.90 ± 6.73

−7.10 ± 1.56

N/A

N/A

    

28

FLEX

31

40.50 ± 9.47

−7.43 ± 1.11

N/A

N/A

    

37

FS-LASIK

35

38.40 ± 44.55

−7.40 ± 1.18

N/A

N/A

Kazutaka Kamiya [49]

2014

Japan

RCT

3

SMILE

24

31.80 ± 6.00

−4.10 ± 1.70

543.10 ± 32.40

13.30 ± 3.20

     

FLEX

24

31.80 ± 6.00

−4.10 ± 1.70

545.50 ± 31.80

13.80 ± 3.30

Di Wu [39]

2014

China

Prospective cohort

6

SMILE

40

25.75 ± 5.40

−5.71 ± 1.19

554.15 ± 24.77

N/A

     

FS-LASIK

40

24.25 ± 6.02

−5.80 ± 1.14

556.70 ± 30.60

N/A

Alper Agca [38]

2014

Turkey

RCT

6

SMILE

30

26.63 ± 4.57

−3.62 ± 1.79

539.00 ± 28.00

N/A

    

FS-LASIK

30

26.63 ± 4.57

−3.71 ± 1.83

542.00 ± 37.00

N/A

Yang Shen [50]

2014

China

Cross-sectional

3

SMILE

17

27.06 ± 6.77

−6.48 ± 1.22

557.65 ± 22.56

N/A

   

LASEK

18

22.89 ± 6.42

−6.09 ± 1.87

533.06 ± 29.38

N/A

   

FS-LASIK

17

29.53 ± 7.42

−8.71 ± 2.02

562.71 ± 20.96

N/A

Rui Dou [51]

2015

China

Retrospective cohort

3

SMILE

36

24.00 ± 8.07

−3.87 ± 0.95

538.00 ± 20.60

15.64 ± 2.04

     

LASEK

35

23.00 ± 3.36

−3.51 ± 1.21

532.00 ± 32.40

15.99 ± 3.50

Shervin Mir Mohi Sefat [25]

2015

Germany

Prospective cohort

3

SMILE

43

36.60 ± 7.70

−3.81 ± 0.95

553.10 ± 29.00

15.80 ± 2.60

   

FS-LASIK

26

36.20 ± 6.70

−3.65 ± 1.12

561.40 ± 30.10

15.90 ± 1.90

Wenjing Wu [40]

2015

China

Retrospective cohort

3

SMILE

75

24.25 ± 5.38

−5.49 ± 1.35

547.69 ± 27.06

15.80 ± 2.55

   

FS-LASIK

75

24.28 ± 5.24

−5.56 ± 1.76

545.97 ± 27.71

15.79 ± 2.78

Hua Li [30]

2016

China

Retrospective cohort

6

SMILE

97

25.00 ± 6.00

−5.60 ± 1.43

546.75 ± 26.06

15.84 ± 2.12

     

FS-LASIK

96

24.00 ± 6.00

−5.95 ± 1.78

542.86 ± 30.54

15.58 ± 2.56

Ihab Mohamed Osman [36]

2016

Egypt

Retrospective cohort

1

SMILE

25

26.28 ± 3.41

−5.43 ± 1.17

532.84 ± 16.37

14.89 ± 3.15

     

LASIK

25

26.88 ± 3.99

−5.16 ± 1.42

527.96 ± 16.21

15.59 ± 3.23

Bingjie Wang [41]

2016

China

Retrospective cohort

12

SMILE

50

25.26 ± 6.64

−7.60 ± 1.12

542.96 ± 23.34

14.68 ± 2.65

  

FS-LASIK

56

24.75 ± 6.24

−7.68 ± 1.19

548.00 ± 23.97

14.94 ± 2.36

Lei Xia [52]

2016

China

Prospective cohort

6

SMILE

69

25.15 ± 4.42

−5.04 ± 2.32

545.50 ± 28.20

N/A

    

FS-LASIK

59

23.65 ± 3.87

−5.13 ± 1.36

538.80 ± 31.50

N/A

Minjie Chen [53]

2016

China

Prospective cohort

3

SMILE

75

26.30 ± 4.20

−4.40 ± 1.00

553.00 ± 26.50

N/A

   

LASEK

76

26.70 ± 5.20

−3.70 ± 1.10

542.40 ± 34.30

N/A

Yusuf Yildirim [54]

2016

Turkey

Retrospective cohort

6

SMILE

42

29.00 ± 5.90

−3.50 ± 1.00

528.10 ± 23.60

N/A

    

PRK

42

27.60 ± 5.20

−3.60 ± 0.60

517.60 ± 24.60

N/A

Jun Zhang [55]

2016

China

Prospective cohort

3

SMILE

80

N/A

−5.12 ± 1.62

550.80 ± 25.77

N/A

     

FS-LASIK

80

N/A

−4.87 ± 1.80

547.06 ± 29.53

N/A

Rohit Shetty [56]

2017

India

RCT

6

SMILE

31

24.00 ± 1.00

−6.18 ± 0.41

514.18 ± 4.50

13.00 ± 0.45

     

FS-LASIK

31

24.00 ± 1.00

−7.22 ± 1.32

517.00 ± 4.89

13.50 ± 0.46

Mohamed Nagy Elmohamady [57]

2018

Egypt

Prospective cohort

36

SMILE

35

24.42 ± 5.91

−8.05 ± 2.06

579.32 ± 10.65

N/A

 

LASIK

30

23.84 ± 4.75

−7.49 ± 2.05

582.84 ± 12.25

N/A

FS-LASIK

38

23.84 ± 4.75

−7.14 ± 1.97

587.96 ± 12.06

N/A

Manrong Yu [58]

2018

China

Prospective cohort

36

SMILE

32

23.40 ± 4.60

−4.10 ± 0.80

551.10 ± 23.10

17.40 ± 4.60

     

LASEK

32

25.70 ± 5.70

−3.70 ± 1.00

538.30 ± 34.60

16.60 ± 2.50

Esraa El-Mayah [59]

2018

Spain

Prospective cohort

3

SMILE

30

29.53 ± 5.37

−4.17 ± 1.86

N/A

N/A

     

FS-LASIK

30

27.40 ± 4.95

−3.97 ± 2.02

N/A

N/A

  1. Abbreviations: CCT central corneal thickness, CH corneal hysteresis, CRF corneal resistance factor, FLEX femtosecond lenticule extraction, FS femtosecond Laser, IOP intraocular pressure, LASEK laser-assisted subepithelial keratectomy, LASIK laser-Assisted in situ keratomileusis, N/A not available, PRK photorefractive keratectomy, RCT randomized controlled trial, SD standard deviation, SE spherical equivalent, SMILE small incision lenticule extraction