Fig. 2

Macular structure monitoring by optical coherence tomography. Optical coherence tomography (OCT) images showing the progression of macular hole formation and closure. a At first visit, OCT shows dense submacular hemorrhage (SMH). The visual acuity (VA) was 20/50. b Three months later, when monthly intravitreal injection of aflibercept (IVA) was administered three times, the SMH decreased. The VA was 20/66. c Ten months later, SMH further decreased and the external limiting membrane (ELM) was found to be perforated. The VA was 20/40. d Twelve months later, MH was observed. The minimum diameter of MH was 145 μm. The VA was 20/50. e Twenty-one months later, the MH had remained for 10 months. The VA increased to 20/25. f Twenty-three months later, serous retinal detachment (SRD) involving the macula appeared, and the MH disappeared. The VA was 20/25 and IVA was performed again. g Twenty-four months later, the SRD was seen to be gradually disappearing, and macular configuration had recovered. The VA was 20/25. h Thirty-eight months later, the SRD had disappeared, and the macular ultrastructure had approached to sound. The VA was 20/20