Table 1 The top 10 significantly enriched KEGG pathways and GO-BP terms of co-DEGs
From: Identification of potential molecular targets associated with proliferative diabetic retinopathy
(a) Up-regulated co-DEGs | |||
Category | Terms | P value | Genes |
GO_BP | GO:0030198~extracellular matrix organization | 1.10E-19 | PXDN, TNF, LUM, TNC, COL3A1... |
GO_BP | GO:0006954~inflammatory response | 9.11E-14 | C3AR1, CCL3, TNF, NMI, TLR1... |
GO_BP | GO:0007155~cell adhesion | 4.44E-12 | TNC, ITGA11, POSTN, IL32, CXCR3... |
GO_BP | GO:0006955~immune response | 3.50E-09 | PXDN, CCL3, TNF, TLR1, CXCL9... |
GO_BP | GO:0001525~angiogenesis | 1.37E-08 | PIK3CG, COL4A2,PGF, HIF1A, PIK3CA... |
GO_BP | GO:0030574~collagen catabolic process | 3.59E-08 | COL4A2, COL4A1, MMP9, COL3A1, COL6A3... |
GO_BP | GO:0030199~collagen fibril organization | 4.34E-08 | LUM, COL3A1, COL1A2, COL1A1, LOX... |
GO_BP | GO:0071347~cellular response to interleukin-1 | 1.04E-06 | ADAMTS7, CCL3, HIF1A, PTGIS, CCL3L1... |
GO_BP | GO:0045766~positive regulation of angiogenesis | 2.34E-06 | C3AR1, CYBB, HIF1A, PTGIS, PGF... |
GO_BP | GO:0050900~leukocyte migration | 4.37E-06 | C3AR1, OLR1, MMP9, F2RL1, ITGA4... |
KEGG_pathway | hsa04512:ECM-receptor interaction | 6.58E-17 | COL4A2, COL4A1, COL3A1, ITGA11, ITGA1... |
KEGG_pathway | hsa04510:Focal adhesion | 1.43E-12 | PGF, TNC, COL3A1, ITGA11, PIK3CA... |
KEGG_pathway | hsa04151:PI3K-Akt signaling pathway | 3.94E-11 | PGF, OSMR, PIK3CA, COL3A1, ITGA11... |
KEGG_pathway | hsa04060:Cytokine-cytokine receptor interaction | 1.04E-08 | CCL3, TNF, TNFSF4, TNFRSF12A, OSMR... |
KEGG_pathway | hsa05146:Amoebiasis | 5.63E-08 | PIK3CG, COL4A2, TNF, COL4A1, COL3A1... |
KEGG_pathway | hsa04620:Toll-like receptor signaling pathway | 4.16E-07 | PIK3CG, IKBKE, CCL3, TNF, CCL3L1... |
KEGG_pathway | hsa05222:Small cell lung cancer | 1.96E-06 | PIK3CG, E2F2, COL4A2, LAMA4, COL4A1... |
KEGG_pathway | hsa05162:Measles | 5.63E-06 | PIK3CG, CD3G, FASLG, CDK6, TLR7... |
KEGG_pathway | hsa04640:Hematopoietic cell lineage | 1.71E-05 | TNF, CD3G, CD36, ITGA5, FCGR1A... |
KEGG_pathway | hsa05205:Proteoglycans in cancer | 2.71E-05 | PIK3CG, TNF, LUM, MMP9, ITGA2... |
(b) Down-regulated co-DEGs | |||
GO_BP | GO:0007601~visual perception | 5.92E-40 | SLC45A2, PITPNA, MYO7A, RRH, RP1L1... |
GO_BP | GO:0001523~retinoid metabolic process | 6.62E-11 | RBP4, OPN1LW, RBP1, RBP3, OPN1MW... |
GO_BP | GO:0006810~transport | 7.57E-11 | RBP7, CRABP1, GABRB3, GRIK1, RBP1... |
GO_BP | GO:0007602~phototransduction | 4.43E-10 | GUCA1B, UNC119, GUCA1A, TRPC3, OPN1LW... |
GO_BP | GO:0042462~eye photoreceptor cell development | 7.94E-10 | GNAT1, TULP1, CRB1, FSCN2, MYO7A... |
GO_BP | GO:0050896~response to stimulus | 8.03E-10 | SLC45A2, CLDN19, IRX5, SLC24A5, RPGRIP1... |
GO_BP | GO:0070588~calcium ion transmembrane transport | 4.64E-08 | TRPM3, SLC8A2, TRPC3, CACNG7, SLC24A5... |
GO_BP | GO:0034220~ion transmembrane transport | 1.57E-07 | FXYD3, ATP1B1, GRIK1, GABRB3, ATP1B2... |
GO_BP | GO:0022400~regulation of rhodopsin mediated signaling pathway | 2.34E-07 | GUCA1B, GNAT1, PDE6A, GUCA1A, PDE6B... |
GO_BP | GO:0042572~retinol metabolic process | 3.37E-07 | RDH12, RDH8, ALDH1A2, TTR, RBP4... |
KEGG_pathway | hsa04744:Phototransduction | 3.68E-10 | GNAT1, GUCA1B, GUCA1A, GUCA1C, CNGB1... |
KEGG_pathway | hsa04724:Glutamatergic synapse | 7.66E-08 | SLC38A3, GNAO1, GRIK1, ADCY5, GNG13... |
KEGG_pathway | hsa04727:GABAergic synapse | 1.03E-07 | GABRG2, GABARAPL1, SLC38A3, GNAO1, GABRB3... |
KEGG_pathway | hsa00350:Tyrosine metabolism | 1.48E-07 | DCT, DDC, TYRP1, TYR, PNMT... |
KEGG_pathway | hsa04723:Retrograde endocannabinoid signaling | 1.36E-06 | GABRG2, GNAO1, GABRB3, ADCY5, GABRB1... |
KEGG_pathway | hsa04721:Synaptic vesicle cycle | 1.37E-05 | CPLX4, SLC17A7, SLC32A1, ATP6V1C2, SLC17A8... |
KEGG_pathway | hsa04261:Adrenergic signaling in cardiomyocytes | 2.72E-05 | ATP1B1, ATP1B2, MYL3, TNNC1, ADCY5... |
KEGG_pathway | hsa05033:Nicotine addiction | 4.19E-05 | SLC17A7, SLC32A1, SLC17A8, GABRG2, GABRR1... |
KEGG_pathway | hsa04020:Calcium signaling pathway | 9.36E-05 | PTGER1, SLC8A2, SLC25A4, CCKBR, TNNC1... |
KEGG_pathway | hsa04725:Cholinergic synapse | 3.05E-04 | GNAO1, ADCY5, GNG13, KCNJ14, GNG8... |