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Table 4 Literature review of studies of corneal endothelial morphology and corneal thickness among various populations

From: Corneal thickness and endothelial morphology in Normal Thai eyes

Study

Population

N (eyes/cases)

Mean Age (range), years

Machines

Mean ECD

(cell/mm)

Cell loss rate (%/year)

Correlation:

ECD and Age

Mean CCT

(μm)

Correlation:

CCT and Age

r

p value

r

p value

Rao et al. 2000 [10]

Indian

1074/537

48 ± 16.5

(20–87)

Konan SP8000, USP(for CCT)

2525 ± 3 37

0.3

−0.387

<  0.001

533 ± 50*

Padilla et al. 2004 [11]

Filipino

640/360

53 ± 17

(20–86)

Konan P9000

2798 ± 307

−0.21

NA

Hashemian et al. 2006 [12]

Iranian

525/525

Only OD

52.7 ± 19.1

(20–80)

Topcon SP2000

1961 ± 457

0.6

−0.64

<  0.001

Yunliang et al. 2007 [13]

Chinese

1329/700

44 ± 21

(10–98)

Konan SP9000

2932 ± 363

0.3

−0.435

0.001

Niederer et al. 2007 [14]

New Zealand

85/NA

38 ± 16

(18–87)

HRT II Rostock Corneal Module

2720 ± 367

0.5

−0.615

<  0.001

555 ± 31

0.148

0.176

Higa et al. 2010 [15]

Japanese

3762/4714

59.1 ± 14.9

(>  40)

Topcon SP2000

2943 ± 387

0.25

− 0.34

<  0.001

NA

Mohammad-Salih et al. 2011 [16]

Malay

125/125

45.8 ± 20.7

(20–87)

Topcon SP3000

2648 ± 310

− 0.300

0.001

Galgauska et al. 2013 [17]

Lithuania

358/211

NA

(20–89)

Konan SP9000

2931 ± 371 ** to

2222 ± 182 ***

−0.650

0.01

563 ± 44* to 540 ± 35**

−0.156

0.01

Arici et al. 2014 [18]

Turkish

252/126

44.3 ± 13.5

(20–70)

Topcon SP3000

2732 ± 305

1.9–5.9

−0.388

<  0.001

521 ± 33

− 0.241

<  0.001

Ewete et al. 2016 [19]

Nigerian

359/201

50.35 ± 20.13

(20–93)

Konan SP9000

2610 ± 371

−0.318

<  0.001

Abdellah et al. 2019 [20]

Egyptian

568/568

49 ± 15.2

(20–85)

Topcon SP-IP

2647 ± 387

0.3

−0.357

<  0.001

514 ± 43

− 0.133

0.007

This study

Thai

1002/501

Only OD

43.12 ± 18.80

(11–88)

Tomey EM4000

2732 ± 258

0.225

−0.484

<  0.001

533 ± 33

− 0.212

<  0.001

  1. ECD endothelial cell density, CCT central corneal thickness, USP ultrasound pachymeter
  2. *CCT decreased with age but not statistically significant, **age 20–29 years old, ***age 80–89 years old